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thoracoscopic
Sponsor study identifier
interventional
155
1 country
1
Study Start
January 2, 2020
Actual (reported)Primary Completion
February 22, 2023
Actual (reported)Study Completion
February 22, 2023
Actual (reported)Acute and chronic postoperative pain remains a major concern following thoracoscopic surgery. Firstly because pain constitutes a serious concern for patients after surgery, and secondarily because an ineffective control of pain may lead to postoperative morbidity, especially in lung cancer surgery. To date, several procedures have been described but the best modality of locoregional analgesia for thoracoscopic surgery has not been assessed yet. The main objective of this study is to evaluate efficiency of several validated approaches for preoperative locoregional analgesia, comparing serratus plain block versus paravertebral block versus serratus plain block and paravertebral block for postoperative pain following thoracoscopic surgery. To this end, the investigators will conduct an interventional prospective monocentric, double blind, compared and randomized study. Previously to thoracoscopic surgery, patients will be randomized in one of the three following arms: serratus plain block, paravertebral block or serratus plain block and paravertebral block combined.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
February 22, 2023
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
November 28, 2019
Actual (reported)January 2, 2020
Actual (reported)January 9, 2020
Actual (reported)February 22, 2023
Actual (reported)February 22, 2023
Actual (reported)Pain Visual analog scale (VAS) score at coughing
Visual analogue scales (VAS) are 10-cm lines anchored at the ends by words that define the bounds of various pain dimensions. The patient is asked to place a vertical mark on the scale to indicate the level of intensity of his or her pain. Numerical rating scales are similar to analogue scales except that numbers (e.g., 0 to 5) are entered along the scale. With category scales, the patient is asked to circle the word that best describes his or her condition (e.g., for pain intensity: None, Moderate, Severe, Unbearable).
Immediately after following thoracoscopic surgery
Pain Visual analog scale (VAS) score at coughing
H1 = one hour following thoracoscopic surgery
Pain Visual analog scale (VAS) score at coughing
H3 = 3 hours following thoracoscopic surgery
Pain Visual analog scale (VAS) score at coughing
H6 = 6 hours following thoracoscopic surgery
Pain Visual analog scale (VAS) score at coughing
Day1 = one day following thoracoscopic surgery
Pain Visual analog scale (VAS) score at coughing
Day2 = two days following thoracoscopic surgery
patient who underwent thoracoscopic surgery will be assigned to serratus plane bloc (Ropivacaine 2 mg/mL, 40 mL) and paravertebral placebo bloc (saline, 20 mL)
patient who underwent thoracoscopic surgery will be assigned to paravertebral bloc (Ropivacaine 4 mg/mL, 20 mL) and serratus plane placebo bloc (saline, 40 mL)
Each patient who underwent thoracoscopic surgery will be assigned to one procedure of Loco-regional anesthesia
Each patient who underwent thoracoscopic surgery will be assigned to one procedure of Loco-regional anesthesia.
CHU Amiens
Amiens, 80054, France
Leviel F, Fourdrain A, Delatre F, De Dominicis F, Lefebvre T, Bar S, Alshatri HY, Lorne E, Georges O, Berna P, Dupont H, Meynier J, Abou-Arab O. S erratus anterior plane block alone, paravertebral block alone and their combination in video-assisted thoracoscopic surgery: the THORACOSOPIC double-blind, randomized trial. Eur J Cardiothorac Surg. 2024 Mar 29;65(4):ezae082. doi: 10.1093/ejcts/ezae082.
Pascal Berna, Pr
CHU Amiens
Emmanuel Lorne, Pr
CHU Amiens
Alex Fourdrain, MD
CHU Amiens
Florent Leviel, MD
CHU Amiens
155 participants (actual enrollment reported by the registry).
First Submitted
November 28, 2019
First Posted
January 9, 2020
Study Start
January 2, 2020
Actual (reported)patient who underwent thoracoscopic surgery will be assigned to serratus plane bloc (Ropivacaine 1,3 mg/mL, 40 mL) and paravertebral bloc (Ropivacaine 1,3 mg/mL, 20 mL)
Each patient who underwent thoracoscopic surgery will be assigned to one procedure of Loco-regional anesthesia.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
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Primary Completion
February 22, 2023
Actual (reported)Study Completion
February 22, 2023
Actual (reported)Last Updated
September 19, 2025
Record last verified: 2025-09
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Source: ClinicalTrials.gov.
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