NCT04219176

Brief Summary

Ocular toxoplasmosis is the most common cause of infectious uveitis worldwide. The diagnosis of ocular toxoplasmosis is primarily clinical when it is a typical presentation .With an atypical presentation in the fundus, parasitological diagnosis is a decisive contribution, as well as multimodal imaging. We investigate on vitreal, retinal, and choroidal morphologic changes in active and scarred toxoplasmosis lesions using swept source optical coherence tomography.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
9

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Jan 2002

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 23, 2002

Completed
15.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 29, 2017

Completed
9 months until next milestone

Study Completion

Last participant's last visit for all outcomes

January 2, 2018

Completed
2 years until next milestone

First Submitted

Initial submission to the registry

December 28, 2019

Completed
9 days until next milestone

First Posted

Study publicly available on registry

January 6, 2020

Completed
Last Updated

January 27, 2020

Status Verified

January 1, 2020

Enrollment Period

15.2 years

First QC Date

December 28, 2019

Last Update Submit

January 22, 2020

Conditions

Ocular Toxoplasmosis

Keywords

Spectral optical coherence tomographyOcular toxoplasmosisUveitis

Outcome Measures

Primary Outcomes (1)

  • number of prticipant affected with ocular toxoplasmosis

    patient diagnosed having ocular toxoplasmosis

    up to one year

Interventions

Spectral optical coherence tomographyDIAGNOSTIC_TEST

Swept-source optical coherence tomography (SS-OCT) is the latest milestone in retinal and choroidal imaging. Because its wavelength of 1050 nm, which is superior to the 840 nm of spectral domain optical coherence tomography (SD-OCT), it is able to overcome ocular opacities such as cataracts and vitritis, wich allows retinal and choroidal visualization of eyes whose fundus is not clearly visible. Consequently , SS-OCT allows visualization of the retinal and choroidal vascular networks, even in eyes with medium opacity

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Nine eyes of nine patients consecutively diagnosed with ocular toxoplasmosis were included in this retrospective study. The patients were examined at ophthalmology service of Farhat Hached Hospital in Sousse Tunisia between January 2002 and December 2017

You may qualify if:

  • all patients hospitalized for ocular toxoplasmosis.

You may not qualify if:

  • patients with non active ocular toxoplasmosis

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Toxoplasmosis, OcularUveitis

Condition Hierarchy (Ancestors)

Eye Infections, ParasiticParasitic DiseasesInfectionsToxoplasmosisCoccidiosisProtozoan InfectionsEye InfectionsEye DiseasesUveal Diseases

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
clinical professor

Study Record Dates

First Submitted

December 28, 2019

First Posted

January 6, 2020

Study Start

January 23, 2002

Primary Completion

March 29, 2017

Study Completion

January 2, 2018

Last Updated

January 27, 2020

Record last verified: 2020-01

Data Sharing

IPD Sharing
Will not share