Immunoblotting and Goldmann-Witmer Coefficient for Ocular Toxoplasmosis
COPILOT
Comparison of Immunoblotting (IgA and IgG) and the Goldmann-Witmer Coefficient for Diagnosis of Ocular Toxoplasmosis in Immunocompetent Patients
1 other identifier
observational
87
1 country
1
Brief Summary
Ocular toxoplasmosis (OT) is a common cause of posterior uveitis worldwide. The diagnosis of OT is based on clinical findings, but in most cases, laboratory tests are required to confirm the etiology, especially when other diseases are suspected. The aim of this study was to evaluate which methods, between the Goldmann-Witmer coefficient (GWC) and immunoblotting (IB) with both IgG and IgA, in aqueous humour (AH) samples, can be the most sensitive to diagnose OT, in current practice, especially in the first three weeks.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Jan 2010
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 31, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
May 31, 2014
CompletedFirst Submitted
Initial submission to the registry
May 10, 2019
CompletedFirst Posted
Study publicly available on registry
May 14, 2019
CompletedMay 14, 2019
May 1, 2019
4.4 years
May 10, 2019
May 10, 2019
Conditions
Outcome Measures
Primary Outcomes (1)
Comparison of Goldmann-Witmer coefficient and immunoblotting results
All tests realized in patients were performed before their repartition in the two groups as well as the biologist could not know the status of the patient. Sensitivity and specificity were calculated for each test.
Assessment of each test result at the inclusion of the patient
Study Arms (2)
Patients with Ocular Toxoplasmosis
Patients without Ocular Toxoplasmosis
Interventions
Aqueous humour sampling with Goldman-Witmer coefficient and immunoblotting
Eligibility Criteria
Patients who had underwent aqueous humor and serum sample for ocular toxoplasmosis
You may qualify if:
- Patients who had underwent aqueous humor and serum sample for ocular toxoplasmosis diagnosis
You may not qualify if:
- Immunocompromised patients
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Service d'ophtalmologie, Hôpital de la Croix-Rousse (HCL)
Lyon, 69004, France
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 10, 2019
First Posted
May 14, 2019
Study Start
January 1, 2010
Primary Completion
May 31, 2014
Study Completion
May 31, 2014
Last Updated
May 14, 2019
Record last verified: 2019-05