Correlation of Serum Lactate and Activity of Multiple Sclerosis

NCT04210960 | Unknown

• 1 other identifier: Mansoura University H 10
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Correlation of serum lactate and activity of multiple sclerosis and its correlation to different type of MS

Conditions

Multiple Sclerosis

Keywords

Multiple sclerosis, serum lactate and MRS

Outcome Measures

Primary Outcomes (1)

• Biochemical testing

  Plasma lactate was assayed according to Trinder method14 . All assays were carried out with Bechman Coulter AU480 autoanalyzer (USA).

  2 days

Study Arms (2)

Patients group

50 multiple sclerosis patients

Radiation: Magentic resonanace imaging; Radiation: Magentic resonanace spectroscopy

Control group

30 normal healthy control

Radiation: Magentic resonanace imaging; Radiation: Magentic resonanace spectroscopy

Interventions

Magentic resonanace imaging RADIATION

The brain MR imaging examinations were done by using a 3 tesla scanner (Acheiva; Philips Medical Systems, Best, Netherlands). All patients were examined in the supine position using head coil. Routine images (T2, T1, FLAIR) and double inversion recovery sequence (DIR) were done to all patients: repetition time (TR) \_ 9583 sec, echo time (TE) \_ 25 sec, inversion time (TI) \_ 3400 sec, IR delay \_ 325 sec, echo train length (ETL) \_ 17, 50 contiguous axial slices, thickness \_ 3 mm, matrix size 240× 142 mm2, field of view (FOV) 230× 184 mm2.

Control group; Patients group

Magentic resonanace spectroscopy RADIATION

Magnetic Resonance (MR) spectroscopy is a noninvasive diagnostic test for measuring biochemical changes in the brain.While magnetic resonance imaging (MRI) identifies the anatomical location of a lesion, MR spectroscopy compares the chemical composition of normal brain tissue with abnormal brain tissue. This test can also be used to detect tissue changes in stroke and epilepsy.

Control group; Patients group

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

80 Egyptian subjects (50 multiple sclerosis patients (patients group = group I) and 30 normal healthy control (control group = group II)

You may qualify if:

• Patients with multiple sclerosis (RRMS,PPMS and SPMS)

You may not qualify if:

• Patients with any other medical conditions that may affect the serum lactate level

Sponsors & Collaborators

• Mansoura University Hospital: lead

Study Sites (1)

Mansoura University Hospital

Al Mansurah, Dakahlia Governorate, 35516, Egypt

RECRUITING

Related Publications (1)

• Esmael A, Talaat M, Egila H, Eltoukhy K. Mitochondrial dysfunction and serum lactate as a biomarker for the progression and disability in MS and its correlation with the radiological findings. Neurol Res. 2021 Jul;43(7):582-590. doi: 10.1080/01616412.2021.1893567. Epub 2021 Mar 4.

  PMID: 33657991 DERIVED

MeSH Terms

Conditions

Multiple Sclerosis

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases

Study Officials

• Esmael M Ahmed, MD

  Assistant Prof of Neurology

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Esmael M Ahmed, MD

CONTACT

00201000372787; deltaneuro@yahoo.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Prof of Neurology

Study Record Dates

• First Submitted: December 22, 2019
• First Posted: December 26, 2019
• Study Start: December 23, 2019
• Primary Completion: May 1, 2020
• Study Completion: June 1, 2020
• Last Updated: December 27, 2019

Record last verified: 2019-12

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)