NCT04210921

Brief Summary

This is a single-blinded, randomized controlled trial to explore the effectiveness of acupuncture in the treatment of the pain due to TMD using the latest diagnostic criteria combined with subjective and objective indexes.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
60

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Apr 2019

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2019

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

November 8, 2019

Completed
2 months until next milestone

First Posted

Study publicly available on registry

December 26, 2019

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2020

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2020

Completed
Last Updated

December 26, 2019

Status Verified

December 1, 2019

Enrollment Period

1.2 years

First QC Date

November 8, 2019

Last Update Submit

December 24, 2019

Conditions

Outcome Measures

Primary Outcomes (1)

  • Visual analogue scale(VAS)

    VAS is an international scale which reflects pain intensity and it has a 10-cm line ranging from 0 cm (no pain at all) to 10 cm (extremely painful). Pain intensity or pain relief in the tempormandibular joints will be measured by VAS. And then the investigators will compare the change of different time frames.The total score of this index is 10, and the better effect with the lower score.

    Baseline,Week- 4(treatment period) and Week-8(follow-up period)

Secondary Outcomes (6)

  • Graded Chronic Pain Scale Version 2.0(GCPS 2.0)

    Baseline,Week- 4(treatment period) and Week-8(follow-up period)

  • Jaw Functional Limitations Scale - 20-item (JFLS-20)

    Baseline,Week- 4(treatment period) and Week-8(follow-up period)

  • Depression, Anxiety and Stress Scales (DASS-21)

    Baseline,Week- 4(treatment period) and Week-8(follow-up period)

  • Pittsburgh sleep quality index (PSQI)

    Baseline,Week- 4(treatment period) and Week-8(follow-up period)

  • Pressure Pain Threshold (PPT)

    Baseline and Week- 4(treatment period)

  • +1 more secondary outcomes

Study Arms (2)

Treatment group

EXPERIMENTAL

In the treatment group, the Park needle with a real acupuncture will be penetrated in an appropriate angle into a depth of 10-15 mm. Acupuncture manually manipulated by lifting, thrusting, and twirling methods to produce a characteristic sensation known as "De Qi" (feeling of needle sensation refers to tenseness around the needle felt by the practitioner and numbness, distension, soreness, and heaviness around the point felt by the patient), and needles will be stimulated manually at least 10 s, then the needles will be retained for 30 minutes.

Device: Acupuncture

Control group

PLACEBO COMPARATOR

In the control group, the Park sham needle will instead of the real needle. It is retractile and adopts the sleeve type blunt needle design. When the blunt needle goes through the adhesive and contact with skin, it will move back into the hollow centre of the handle rather than penetrate into skin. The sham needle may be manipulated by lifting, thrusting or twirling as the real one, but it will not insert into the skin authentically.

Device: The park sham needle

Interventions

The acupuncture will be penetrated in an appropriate angle into a depth of 10-15 mm. Acupuncture manually manipulated by lifting, thrusting, and twirling methods to produce a characteristic sensation known as "De Qi" .

Treatment group

When the blunt needle goes through the adhesive and contact with skin, it will move back into the hollow centre of the handle rather than penetrate into skin.

Control group

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Pain disorders in accordance with Diagnostic Criteria for Temporomandibular Disorders (DC/TMD)
  • Pain in the jaw, temple, in the ear, in front of ear or headache in the temple at any sides, and pain or headache modified (remission or aggravation) with movement at least 3 months.
  • Cooperated in completing the clinical trial successfully without language and mental disorders.

You may not qualify if:

  • Conditions that result in regional pain in temporomandibular joint.
  • Autoimmune diseases that result in regional pain in the temporomandibular joint.
  • Mental illness or substance abuse.
  • Pregnant women.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Beijing Hospital of Traditional Chinese Medicine affiliated to the Capital Medical University

Beijing, China

RECRUITING

MeSH Terms

Conditions

Temporomandibular Joint Disorders

Interventions

Acupuncture Therapy

Condition Hierarchy (Ancestors)

Craniomandibular DisordersMandibular DiseasesJaw DiseasesMusculoskeletal DiseasesJoint DiseasesMuscular DiseasesStomatognathic Diseases

Intervention Hierarchy (Ancestors)

Complementary TherapiesTherapeutics

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Acupuncture director

Study Record Dates

First Submitted

November 8, 2019

First Posted

December 26, 2019

Study Start

April 1, 2019

Primary Completion

June 30, 2020

Study Completion

June 30, 2020

Last Updated

December 26, 2019

Record last verified: 2019-12

Locations