NCT04209413|Unknown
Control of the Opening of mPTP by Ex Vivo Measurements on Permeabilized Muscle Fibers (COMMEF)
COMMEF
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COMMEF
Sponsor study identifier
Secondary identifiers
OTHER · ANSM
observational
40
1 country
1
Study Start
January 20, 2020
Actual (reported)Primary Completion
November 2020
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
February 2021
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
mPTP (Mitochondrial Permeability Transition Pore) is a channel formed by a protein complex integrated into the inner membrane of mitochondria. Its opening is related to the elevation of the intra-mitochondrial calcium concentration and will result in: a mitochondrial decoupling, a rupture of the metabolic gradient and the release of pro-apoptotic factors. The objective of this study is the development of a new ex vivo technique for characterizing mPTP by a dual measurement combining oxygraphy and fluorimetry on permeabilized skeletal muscle fibers.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
February 2021
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
December 20, 2019
Actual (reported)December 24, 2019
Actual (reported)January 20, 2020
Actual (reported)November 2020
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
February 2021
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Determination of the mPTP calcium sensitivity mPTP
The goal is to study the feasibility of a new method for the analysis of the calcium sensitivity of mPTP on non-phantomized permeabilized muscle fibers by coupled use of oxygen and fluorimetry techniques. Calcium quantity and time required to open mPTPs in permeabilized muscle fibers will be measured, in the presence or absence of ciclosporin A, observable by total inhibition of mitochondrial respiration (synonymous with release of NADH).
day 0
Identification of mPTP opening discrimination factors
Day 0
knee ligamentoplasty
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Patients referred for a knee ligamentoplasty
CHU de Clermont-Ferrand
Clermont-Ferrand, 63000, France
Ruddy Richard
University Hospital, Clermont-Ferrand
First Submitted
December 20, 2019
First Posted
December 24, 2019
Study Start
January 20, 2020
Actual (reported)Primary Completion
November 2020
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
The Role of Muscle in Knee Stability
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Study Completion
February 2021
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
January 22, 2020
Record last verified: 2020-01
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Source: ClinicalTrials.gov.
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