Can Sensorimotor Function Predict Graft Rupture After ACL Reconstruction

NCT04162613 | Completed

• 1 other identifier: STOP Graft Rupture
• Study Type: observational
• Target: 201
• Locations: 1 country
• Sites: 1

Brief Summary

In this longitudinal prospective cohort study including young people with anterior cruciate ligament (ACL) reconstruction, the investigators will evaluate if poor sensorimotor function at baseline can predict 1) graft rupture 2) the risk of contra-lateral ACL injury and 3) failure to return to sport/previous activity level within 3 years following ACL reconstruction.

Conditions

Anterior Cruciate Ligament Injuries

Keywords

anterior cruciate ligament injury; re-injury; muscle function; functional performance; rehabilitation; physiotherapy; sensorimotor control

Outcome Measures

Primary Outcomes (1)

• Number of participants with graft rupture

  Number of patients that have sustained a rupture of the reconstructed ligament

  2 years

Secondary Outcomes (2)

• Number of patients with contra-lateral ACL injury

  2 years

• Failure to return to sport/previous activity level

  2 years

Study Arms (1)

Patients with ACL reconstruction in Lund and Umeå

Persons who have suffered a unilateral anterior cruciate ligament injury treated with reconstruction

Other: Different measures of muscle function such as muscle strength, hop tests, postural orientation and muscle activation

Interventions

Different measures of muscle function such as muscle strength, hop tests, postural orientation and muscle activation OTHER

The participants will be assessed with a physical test battery at baseline including: Isokinetic knee strength, Isometric strength of trunk and lower extremity, Single-leg hop for distance, side hop, postural orientation (single leg-squat, stair descending, forward lunge, Single-leg hop for distance, side-hop), hip and ankle range of joint motion, muscular activation pattern, 3D movement analysis and proprioception test. At follow-up (2 years), the participants will be asked to answer a survey about new ACL injuries and return to sport/previous activity level.

Patients with ACL reconstruction in Lund and Umeå

Eligibility Criteria

• Age: 15 Years - 35 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Patients will be recruited from the Department of Orthopedics, Norrland University hospital, Umeå, Sweden and Skåne University Hospital, Lund, Sweden.

You may qualify if:

• months after ACL reconstruction
• With or without associated injuries to other structures of the knee (e.g., collateral ligament(s), meniscal injury)
• Age 15-35 years.

You may not qualify if:

• ACL injury other knee and previous ACL injury index knee
• Diseases or disorders overriding the knee condition (e.g., neurological or rheumatological disease)
• Not understanding the languages of interest (any Scandinavian language or English).

Sponsors & Collaborators

• Umeå University: lead
• Lund University: collaborator

Study Sites (1)

UMotion laboratory

Umeå, 90746, Sweden

Location

Related Publications (1)

• Cronstrom A, Ageberg E, Hager CK. Does sensorimotor function predict graft rupture, contra-lateral injury or failure to return to sports after ACL reconstruction? A protocol for the STOP Graft Rupture study. BMJ Open. 2021 Jan 8;11(1):e042031. doi: 10.1136/bmjopen-2020-042031.

  PMID: 33419913 DERIVED

MeSH Terms

Conditions

Anterior Cruciate Ligament Injuries; Reinjuries

Interventions

Muscle Strength

Condition Hierarchy (Ancestors)

Knee Injuries; Leg Injuries; Wounds and Injuries

Intervention Hierarchy (Ancestors)

Physical Examination; Diagnostic Techniques and Procedures; Diagnosis; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Anna Cronström, PhD

  Umeå University

  PRINCIPAL INVESTIGATOR

• Charlotte Häger, Professor

  Umeå University

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 11, 2019
• First Posted: November 14, 2019
• Study Start: October 1, 2019
• Primary Completion: February 15, 2026
• Study Completion: February 15, 2026
• Last Updated: April 29, 2026

Record last verified: 2026-04

Locations

SE (1)