NCT04207853

Brief Summary

Introduction: Diabetes Mellitus (DM) is an important health condition of the population and its prevalence continues to grow due to population aging, economic development and urbanization. The exercise is an important factor of prevention and control, thereby decreasing the risk of metabolic diseases, cardiovascular diseases and improving the functionality of the patient with diabetes. Objective: Evaluate the response of resistance training associated with wholebody vibration on peripheral circulation and functional performance of elderly with type 2 diabetes. Methods: This is a clinical trial study, controlled, randomized and blinded, which will follow the guidelines established by the Consolidated Standards of Reporting Trials (CONSORT). Patients will be recruited in the light of the eligibility criteria and randomly divided into 3 groups: resistance training associated with whole body vibration (G1), resistance training associated with vibration sham (G2) and control group-guidelines about foot care (GC), establishing 36 treatment sessions, three times a week for the G1 and G2.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
30

participants targeted

Target at below P25 for not_applicable diabetes-mellitus-type-2

Timeline
Completed

Started Aug 2019

Shorter than P25 for not_applicable diabetes-mellitus-type-2

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 8, 2019

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

October 18, 2019

Completed
2 months until next milestone

First Posted

Study publicly available on registry

December 23, 2019

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 20, 2020

Completed
8 days until next milestone

Study Completion

Last participant's last visit for all outcomes

February 28, 2020

Completed
Last Updated

December 23, 2019

Status Verified

December 1, 2019

Enrollment Period

7 months

First QC Date

October 18, 2019

Last Update Submit

December 20, 2019

Conditions

Keywords

Diabetes MellitusSkin TemperatureCirculationPeripheral SensitivityPlantar PressureVibration

Outcome Measures

Primary Outcomes (4)

  • skin temperature

    Infrared Thermography (TI)

    " until study completion, an average of 2 months".

  • circulation

    Vascular Doppler ultrasound (UVD)

    " until study completion, an average of 2 months".

  • peripheral sensitivity

    Esthesiometer

    " until study completion, an average of 2 months".

  • plantar pressure

    Baropodometry

    " until study completion, an average of 2 months".

Study Arms (6)

whole body vibration in diabetics (G1)

EXPERIMENTAL

One 24Hz session, 4mm amplitude, 8 rep series, 45s intervention time, 30s recovery

Other: whole body vibration em DM

the sham vibration group in diabetics (G2)

SHAM COMPARATOR

dummy vibration (sound stimulus), 8-rep series, 45s intervention time, 30s recovery

Other: Vibration "sham" em DM

diabetic control group (G3)

NO INTERVENTION

no treatment

whole body vibration group in non-diabetics (G4)

ACTIVE COMPARATOR

One 24Hz session, 4mm amplitude, 8 rep series, 45s intervention time, 30s recovery

Other: whole body vibration em NDM

the vibration group " sham "in non-diabetics (G5)

SHAM COMPARATOR

dummy vibration (sound stimulus), 8-rep series, 45s intervention time, 30s recovery

Other: Vibration "sham" em NDM

non-diabetic control group (G6)

NO INTERVENTION

no treatment

Interventions

The vibrating platform is a new biophysical modality of exercise. The individual exercises on a plate that oscillates up and down movements at a specific frequency and amplitude, and the exercises are performed static and / or dynamic. Vibration is supposed to activate muscle spindles and evoke contractions, which are induced by the complex spinal and supraspinal neurophysiological mechanism known as the tonic vibration reflex.

whole body vibration in diabetics (G1)

Sham vibration will be performed with the platform disconnected. A sound device will be connected producing a noise similar to the connected platform for a time equivalent to the treatment protocol, as it will not be possible to visibly distinguish the vibratory stimulus. Participants who will undergo false vibration will not have contact with those who will perform the protocol effectively.

the sham vibration group in diabetics (G2)

The vibrating platform is a new biophysical modality of exercise. The individual exercises on a plate that oscillates up and down movements at a specific frequency and amplitude, and the exercises are performed static and / or dynamic. Vibration is supposed to activate muscle spindles and evoke contractions, which are induced by the complex spinal and supraspinal neurophysiological mechanism known as the tonic vibration reflex.

whole body vibration group in non-diabetics (G4)

Sham vibration will be performed with the platform disconnected. A sound device will be connected producing a noise similar to the connected platform for a time equivalent to the treatment protocol, as it will not be possible to visibly distinguish the vibratory stimulus. Participants who will undergo false vibration will not have contact with those who will perform the protocol effectively.

the vibration group " sham "in non-diabetics (G5)

Eligibility Criteria

Age45 Years - 80 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • (I) Diabetics classified clinically as type 2 diagnosed more than 2 years and less than 20 years of diagnosis; (II) Patients of both sexes aged between 45 and 80 years; (III) Be functionally independent; (IV) Possess cognitive ability to answer and perform the exercises evaluated by the Mini-Mental State Examination (MMSE); (V) Patients without severe foot deformities requiring therapeutic footwear; (VI) Not having orthopedic disabilities; (VII) No indications of deep vein thrombosis; (VIII) Not making use of mobility aids (IX) Presenting BMI between 18.50 and 34.99kg / m2; (X) For the control group participants must fulfill all of the above requirements except item I.

You may not qualify if:

  • (I) Type I diabetics; (II) Diabetics and non-diabetics who are performing physical activity or who have performed any type of physical activity less than 2 months; (III) Have lower limb amputation; (IV) Patients with vertigo or labyrinthitis; (V) Have blood pressure greater than or equal to 150/100 mmHg or less than or equal to 60/40 mmHg.
  • (VI) Presence of rheumatic diseases; (VII) Chemical dependents; (VIII) Blood glucose greater than 300mg/dL.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Universidade Federal de Pernambuco

Recife, Pernambuco, 50740560, Brazil

RECRUITING

MeSH Terms

Conditions

Diabetes Mellitus, Type 2Diabetes Mellitus

Condition Hierarchy (Ancestors)

Glucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System Diseases

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR
Masking Details
group the patient will enter. The patient will be allocated among three groups. After the final evaluations, all data will be analyzed by another researcher directed solely to that purpose. Therefore, there will be a triple blinding (researcher, patient and statistician).
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: 6 groups: whole body vibration in diabetics (G1), the sham vibration group in diabetics (G2) and diabetic control group (G3), the whole body vibration group in non-diabetics (G4), the vibration group " sham "in non-diabetics (G5) and non-diabetic control group (G6), establishing a single treatment session for G1, G2, G4 and G5.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Doutor

Study Record Dates

First Submitted

October 18, 2019

First Posted

December 23, 2019

Study Start

August 8, 2019

Primary Completion

February 20, 2020

Study Completion

February 28, 2020

Last Updated

December 23, 2019

Record last verified: 2019-12

Data Sharing

IPD Sharing
Will not share

Locations