Diabetes Resistance Training Adaptations in Elderly

NCT02548000 | Completed

• 1 other identifier: 150257
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 2

Brief Summary

This study aims to verify the effects of resistance training on neuromuscular, vascular and functional adaptations of elderly diabetics type 2. Half of participants will be the intervention group that will perform resistance training, while the other half will be the control group that will perform stretching sessions.

Conditions

Diabetes Mellitus, Type 2

Outcome Measures

Primary Outcomes (1)

• Quadriceps Muscle Quality measure by echo intensity

  Echo intensity is a grey scale for analyse the image that ranging from 0 (black) to 255 (white).

  12 weeks

Secondary Outcomes (12)

• Functional capacity measure by stair climb test.

  12 weeks

• Quadriceps muscle strength measured by one repetition maximum (1RM) test.

  12 weeks

• Visceral adipose tissue measured by ultrasonography

  12 weks

• Muscle thickness measured by ultrasonography

  12 weeks

• Inflammation status estimated by tumor necrosis factor alpha (TNF-α ) and C reactive protein (CRP)

  12 weeks

Study Arms (2)

Resistance training

EXPERIMENTAL

Resistance training will be performed three times a week, for 12 weeks, composed by 12 resistance exercises for all body muscles with 2-3 series and 12-8 repetitions in each exercise.

Other: Resistance training

Stretching control

ACTIVE COMPARATOR

The control group will perform one stretching session a week.

Other: Stretching control

Interventions

Resistance training OTHER

The resistance training will be compound by 12 exercises for all body muscles, performed three times per week. The intensity of training will be measure by maximum repetitions from 12 until 8 repetitions with 2-3 series. The loads will increase for keep the maximum strength as the capacity of patients. The blood pressure and the casual glycemic will be measure before and after the training in each session. Before to start the exercises, patients will perform a warming on treadmill for 10 minutes and after the training will perform some stretching exercises for muscles groups trained.

Resistance training

Stretching control OTHER

The stretching session will be composed by stretching and joint mobilization exercises for all body muscles and will happen only one time per week.

Stretching control

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Type 2 diabetes
• yers and older
• HbA1c \> 6,5%
• BMI from 18,5 kg/m2 - 34,9 kg/m2

You may not qualify if:

• Current smoking
• Insulin users
• Hypertension uncontrolled
• Diabetic neuropathy
• Diabetic retinopathy
• Diabetic nephropathy
• Peripheral amputations
• Clinical depression
• Myocardial infarction (within past 6 months)
• Any unstable chronic condition
• Muscle-skeletal complications that limit the practice of the exercises

Sponsors & Collaborators

• Hospital de Clinicas de Porto Alegre: lead
• Federal University of Rio Grande do Sul: collaborator

Study Sites (2)

Hospital de Clinicas de Porto Alegre

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil

Location

Federal University of Rio Grande do Sul, Physical Education School

Porto Alegre, Rio Grande do Sul, 90690-000, Brazil

Location

MeSH Terms

Conditions

Diabetes Mellitus, Type 2

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Alexandre S Dias, phd

  Hospital de Clinicas de Porto Alegre

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 25, 2015
• First Posted: September 14, 2015
• Study Start: July 1, 2015
• Primary Completion: December 1, 2016
• Study Completion: July 1, 2017
• Last Updated: August 3, 2017

Record last verified: 2017-08

Locations

BR (2)