Cancer Sensing: Evaluation of Odour Sampling Techniques

NCT04206995 | Completed

• 1 other identifier: Skin cancer sensing by VOCs
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 2

Brief Summary

To evaluate the suitability of two odour capturing techniques for early detection of skin cancer.

Conditions

Skin Cancer

Outcome Measures

Primary Outcomes (2)

• Evaluate the suitability of the adsorptive patch for collecting VOCs for analysis for early identification of skin cancer.

  An adsorptive patch, covering skin cancer and healthy skin sites will be applied for a period of maximum 30 minutes to capture VOCs. No drug will be used. This is to investigate the capability of the technique in capturing VOCs.VOCs for analysis for early identification of skin cancer.

  30 minutes

• Evaluate the suitability of the Solid Phase Microextraction (SPME) for analysis for early identification of skin cancer.

  A SPME fibre is held directly above skin cancer, or healthy skin for a period of less than 30 minutes to capture VOCs. No drug will be used. This is to investigate the capability of the technique in capturing VOCs.

  30 minutes

Study Arms (1)

Evaluation of odour capturing techniques

To evaluate two odour capturing techniques to compare VOC profiles of cancerous and healthy skin cancer.

Other: Solid Phase Microextraction (SPME); Other: Absorptive patch

Interventions

Solid Phase Microextraction (SPME) OTHER

A SPME fibre is held directly above skin cancer, or healthy skin for a period of less than 30 minutes to capture VOCs. No drug will be used. This is to investigate the capability of the technique in capturing VOCs.

Evaluation of odour capturing techniques

Absorptive patch OTHER

An adsorptive patch, covering skin cancer and healthy skin sites will be applied for a period of maximum 30 minutes to capture VOCs. No drug will be used. This is to investigate the capability of the technique in capturing VOCs.

Evaluation of odour capturing techniques

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Skin odour samples are obtained from patients who are diagnosed with cancer and during their visit to Poole or Dorset County Hospitals. Skin odour samples of healthy people will also be obtained from staff and students at Bournemouth University.

You may qualify if:

• Patients diagnosed with skin cancer, able to speak and understand written English,
• years or older and
• Capable of giving informed consent.

You may not qualify if:

• Patients too weak to speak or give written informed consent;
• Non-English speaking without an interpreter;
• Patients lacking mental capacity to consent, or
• Below the age of 18.

Sponsors & Collaborators

• Bournemouth University: lead
• Poole Hospital NHS Foundation Trust: collaborator
• Dorset County Hospital NHS Foundation Trust: collaborator

Study Sites (2)

Dorset County Hospital NHS Foundation Trust

Dorchester, Dorset, DT1 2JY, United Kingdom

Location

University Hospitals Dorset NHS Foundation Trust

Poole, Dorset, BH15 2JB, United Kingdom

Location

MeSH Terms

Conditions

Skin Neoplasms

Interventions

Solid Phase Microextraction

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Skin Diseases; Skin and Connective Tissue Diseases

Intervention Hierarchy (Ancestors)

Solid Phase Extraction; Chemical Fractionation; Chemistry Techniques, Analytical; Investigative Techniques

Study Officials

• Richard Paul, PhD

  Bournemouth University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 13, 2019
• First Posted: December 20, 2019
• Study Start: September 1, 2021
• Primary Completion: November 18, 2021
• Study Completion: November 18, 2021
• Last Updated: January 5, 2022

Record last verified: 2022-01

Locations

GB (2)