Skin Ageing Signatures and Cancer

NCT03265678 | Completed

• 1 other identifier: 11701
• Study Type: observational
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to identify genetic patterns in normal ageing skin in order to better understand age-related changes. Data has suggested that skin ageing has a genetic basis and past studies have identified genes that promote skin aging due to sun exposure.

Conditions

Skin Cancer

Outcome Measures

Primary Outcomes (1)

• Recruitment of 10 patients with high or low skin ageing scores and collection of normal sun exposed and non-sun exposed skin and blood for genetic analysis.

  Identify a genomic/transcriptomic molecular signature for skin ageing by correlation of whole genome sequencing and transcriptomic profiles of normal skin and clinically evaluated skin ageing scores

  1 Year

Secondary Outcomes (1)

• Whole genome sequencing and transcriptomic analysis of normal skin samples

  1 Year

Study Arms (1)

Arm

Registered participants will undergo a clinical assessment to determine whether they have high or low levels of skin ageing. The study will recruit 5 subjects with low levels of skin ageing and 5 subjects with high levels of skin ageing. Recruited patients will undergo skin punch biopsies, blood sampling and collection of lifestyle data.

Eligibility Criteria

• Age: 55 Years - 65 Years
• Gender Eligibility Details: Only female participants will be approached for the study
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Potential participants will be identified amongst patients attending outpatient clinics in dermatology, ophthalmology and other general medical specialities for reasons other than skin cancer or inflammatory skin disease. If required, volunteers will also be recruited by advertising from amongst staff within the hospital and Queen Mary University of London. Participants will be identified by the dermatology consultant or research fellow working on this study.

You may qualify if:

• Able to give written informed consent prior to admission to this study.
• Female aged between 55 and 65 years.
• Willing and able to comply with clinical/photographic assessment and laboratory tests

You may not qualify if:

• Previous history of skin cancer, active inflammatory or other skin condition that in the opinion of the investigator may affect the skin ageing assessment.
• Feverish symptoms which lasted for ≥48 hours prior to study entry.
• Currently suffering from or having suffered during the last month, with any common systemic disease except arterial hypertension.
• Received any of the following treatment for more than 6 months during the last two years: hypo or hyperthyroidism treatment, corticoids, non-steroids anti-inflammatory, antihistamines, immunosuppressive treatments, diuretics, antibiotics, anticoagulants, beta blockers.
• Currently experiencing or having experienced in the last two months prior to study entry problems affecting the skin of the face or forearm for instance acne, eczema, psoriasis, seborroheic dermatitis, herpes zoster.
• Currently receiving or having received in the last two months prior to study entry any of the following dermatological treatments for more than 8 days: hormone based cream, retinoid based facial cream, \> 8% concentration alpha hydroxy acid based cream, topical steroids, antibiotics and antifungals
• Previous facial aesthetic treatments such as: lifting, chemical peeling, dermabrasion, electrocoagulation, laser, sclerotherapy, reconstructive surgery, botox injection, filler injection.
• Currently using a hormone based cream that is applied on the forearm for hormonal replacement therapy.
• Have had a change in skin colour during within one month prior to study entry due to sun exposure
• Had a session of UV therapy for treatment purposes or in a beauty salon within one month prior to study entry.
• Use of a self-tanning product

Sponsors & Collaborators

• Queen Mary University of London: lead
• University of Edinburgh: collaborator

Study Sites (1)

Barts Health NHS Trust

London, E1 1BB, United Kingdom

Location

Biospecimen

Retention: SAMPLES WITH DNA

Skin and blood samples

MeSH Terms

Conditions

Skin Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Skin Diseases; Skin and Connective Tissue Diseases

Study Officials

• Prof Catherine Harwood

  Queen Mary University of London

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 25, 2017
• First Posted: August 29, 2017
• Study Start: June 2, 2017
• Primary Completion: January 22, 2018
• Study Completion: January 22, 2018
• Last Updated: April 23, 2024

Record last verified: 2024-04

Locations

GB (1)