Ischemic Stroke, Obesity and Thrombolysis
ISOT
1 other identifier
observational
280
1 country
2
Brief Summary
This study focuses on the relationship between obesity and stroke, which are both characterized by increasing incidence and prevalence with epidemic proportions worldwide and tremendous socio-economic consequences. Furthermore, obesity is an established risk factor for stroke and affects especially younger people, which increases the stroke incidence in younger patients. Unfortunately, the relationship between overweight and acute ischemic stroke including treatment by thrombolysis has not yet been evaluated thoroughly.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Mar 2015
Longer than P75 for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2015
CompletedFirst Submitted
Initial submission to the registry
December 6, 2019
CompletedFirst Posted
Study publicly available on registry
December 12, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 29, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
March 31, 2024
CompletedDecember 6, 2024
December 1, 2024
9 years
December 6, 2019
December 5, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Rates of favourable clinical outcome (mRS 0-2) and death
Month 3
Secondary Outcomes (4)
Symptomatic intracranial hemorrhage at 24h after intravenous thrombolysis
Day 1
Recanalisation rates of vessel occlusion at 24h after thrombolysis
Day 1
In-hospital complications
Day 1
Stroke recurrence and myocardial infarction within 12 months after thrombolysis
Month 12
Eligibility Criteria
All patients receiving thrombolytic treatment for acute ischemic stroke will be included in this study.
You may qualify if:
- Acute ischemic stroke
- Acute treatment with thrombolysis
- Age \>18 years
- Written informed consent
You may not qualify if:
- Age \<18 years
- Intracranial hemorrhage
- Known hemorrhagic diathesis
- Preexisting neurological deficits (mRS \>2 points)
- Uncontrolled arterial hypertension (blood pressure \>185/110 mmHg repeatedly despite antihypertensive drugs)
- Severe illness with poor prognosis (e.g. neoplasia)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
Kantonsspital St.Gallen
Sankt Gallen, Switzerland
University Hospital Zurich
Zurich, Switzerland
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Hakan Sarikaya, PD Dr.med.
Insel Gruppe AG, University Hospital Bern
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
December 6, 2019
First Posted
December 12, 2019
Study Start
March 1, 2015
Primary Completion
February 29, 2024
Study Completion
March 31, 2024
Last Updated
December 6, 2024
Record last verified: 2024-12
Data Sharing
- IPD Sharing
- Will not share