NCT02470624

Brief Summary

This is a multi-center registry study. The investigators will include 10,000 patients with confirmed acute ischemic stroke in China. The aim of the study is to survey current treatment situation in China and compare the effectiveness and safety between different intervention regimens.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
10,000

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started May 2015

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2015

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

June 10, 2015

Completed
2 days until next milestone

First Posted

Study publicly available on registry

June 12, 2015

Completed
1.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2017

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2017

Completed
Last Updated

October 23, 2015

Status Verified

October 1, 2015

Enrollment Period

1.8 years

First QC Date

June 10, 2015

Last Update Submit

October 22, 2015

Conditions

Ischemic Stroke

Outcome Measures

Primary Outcomes (1)

  • death or severe disability

    90 days

Study Arms (1)

treatment following current guideline

Other: treatment following current guideline

Interventions

treatment following current guidelineOTHER
treatment following current guideline

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

acute ischemic stroke patients

You may qualify if:

  • age ≥18 yesrs
  • confirmed diagnosis of an ischemic stroke
  • admission within 1 week after onset of stroke or within treatment time window for patients of thrombolysis treatment
  • signed informed consent

You may not qualify if:

  • with intracerebral hemorrhage
  • with severe morbid (estimated survival duration less than 3 months)
  • could not provide follow-up information

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Peking University First Hospital

Beijing, 100034, China

RECRUITING

Related Publications (6)

  • Huang D, Lu Y, Sun W, Sun W, Sun Y, Huang Y, Song Y, Tai L, Li G, Chen H, Zhang G, Zhang L, Sun X, Qiu J, Wei Y, Jin H. Functional Outcomes of Human Urinary Kallindinogenases in Treatment of Acute Ischemic Stroke. Stroke. 2026 Jan;57(1):63-76. doi: 10.1161/STROKEAHA.124.050188. Epub 2025 Sep 29.

    PMID: 41017461DERIVED

  • Lu Y, Sun W, Huang Y, Wang Z, Shen Z, Sun W, Liu R, Li F, Shu J, Peng Q, Jia J, Sun P, Song Y, Jin H; CASTOR Investigators. Comparison of Factors Affecting Quality of Life in Patients with Acute Ischemic Stroke Across Different Stroke Severities. Neurol Ther. 2025 Jun;14(3):1023-1038. doi: 10.1007/s40120-025-00743-9. Epub 2025 Apr 29.

    PMID: 40301282DERIVED

  • Wang L, Guan X, Zhou J, Hu H, Liu W, Wei Q, Huang Y, Sun W, Jin X, Li H. Measuring the health outcomes of Chinese ischemic stroke patients based on the data from a longitudinal multi-center study. Qual Life Res. 2025 Jul;34(7):1967-1977. doi: 10.1007/s11136-025-03957-4. Epub 2025 Mar 27.

    PMID: 40146503DERIVED

  • Lu Y, Sun P, Jin H, Wang Z, Shen Z, Sun W, Sun Y, Liu R, Li F, Shu J, Qiu Z, Lu Z, Sun W, Zhu S, Huang Y; CASTOR Investigators. Prolonged Hospital Length of Stay Does Not Improve Functional Outcome in Acute Ischemic Stroke. Neurol Ther. 2025 Apr;14(2):593-607. doi: 10.1007/s40120-025-00712-2. Epub 2025 Feb 18.

    PMID: 39964661DERIVED

  • Li Y, Ou Q, Lu Y, Shen Z, Li J, Zhang Z, Tai L, Li G, Chen H, Zhang G, Zhang L, Sun X, Qiu J, Wei Y, Zhu S, Wang Z, Sun W, Huang Y. Geographic differences in pharmacotherapy patterns and outcomes of acute ischemic stroke in China. BMC Neurol. 2024 Feb 15;24(1):64. doi: 10.1186/s12883-024-03564-9.

    PMID: 38360588DERIVED

  • Sun W, Ou Q, Zhang Z, Qu J, Huang Y. Chinese acute ischemic stroke treatment outcome registry (CASTOR): protocol for a prospective registry study on patterns of real-world treatment of acute ischemic stroke in China. BMC Complement Altern Med. 2017 Jul 6;17(1):357. doi: 10.1186/s12906-017-1863-4.

    PMID: 28683732DERIVED

MeSH Terms

Conditions

Ischemic Stroke

Condition Hierarchy (Ancestors)

StrokeCerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular Diseases

Study Officials

  • Yining Huang, MD

    Peking University First Hospital

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Yining Huang, MD

CONTACT

+86(10)83572857ynhuang@sina.com

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
18 Months
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

June 10, 2015

First Posted

June 12, 2015

Study Start

May 1, 2015

Primary Completion

March 1, 2017

Study Completion

March 1, 2017

Last Updated

October 23, 2015

Record last verified: 2015-10

Locations

CN(1)