Hyperglycemia as a Prognostic Factor In Acute Ischemic Stroke Patients

NCT04196322 | Completed DMC

• 1 other identifier: El Zaitoun Specialized Hospita
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Background: Hyperglycemia is encountered in 20% to 40% of acute stroke patients, with or without a pre-morbid diagnosis of diabetes mellitus. Hyperglycemia is a risk factor for infarct expansion and poor outcome through the first 72 hours of onset in both diabetics and non-diabetics patients. This study was done to evaluate the glycemic status after acute ischemic stroke and assess its rule in influencing stroke outcome as regards the duration of hospital stay, motor deficit and mortality. Methods: This retrospective study was conducted in Elzaiton specialized hospital from June 2016 to June 2017on 80 patients after approval of local medical ethical committee. Patients with acute ischemic stroke without other major comorbidities within 24 hours of onset of symptoms were included and divided into two groups, controlled group (Random blood suger not more than 150 mg/dl) and uncontrolled group ( Random blood suger more than 150 mg/dl). All patients were evaluated for GCS as a primary outcome and for hemorrhagic transformation, hospital stay duration, mechanical ventilation, need for vasopressors,hospital stay and mortality as secondary outcomes.

Conditions

Acute Ischemic Stroke Patients

Outcome Measures

Primary Outcomes (1)

• GCS

  GCS was assessed for 30 days

  30 days

Secondary Outcomes (1)

• 30 days mortality

  30 days

Study Arms (2)

Controlled

Other: observational study

Uncontrolled

Other: observational study

Interventions

observational study OTHER

observational study

Controlled; Uncontrolled

Eligibility Criteria

• Age: 40 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with acute ischemic stroke without other major comorbidities within 24 hours of onset of symptoms will be evaluated. At ICU admission the random blood sugar was recorded and categorized to less than 150mg/dl (accepted) and more than 150mg/dl(not controlled). Also serial Random blood sugar daily was recorded and categorized to accepted or good control if less than 150mg/dl and not controlled if more than 150mg/dl. Patients were divided into 2 groups Patients with accepted random blood sugar at admission and controlled blood sugar during hospital stay (B) Patients with increased random blood sugar at admission and poor blood sugar control during hospital stay These data were collected and patients were observed as regards duration of hospital stay, motor deficit improvement or worsening using Rating scale for muscle strength

You may qualify if:

• Age: 40-70years
• Sex: Any sex
• Patients with acute ischemic stroke without other major comorbidities within 24 hours of onset of symptoms were evaluated.

You may not qualify if:

• Subdural heamatoma, metabolic causes or transient ischemic attack
• Sub arachnoid heamorrage
• Heamorragic stroke
• Patients with major comorbidities at admission as end stage liver disease, end stage renal disease and malignant hypertension
• Patients with hyperglycemia at admission and controlled blood sugar during hospital stay
• Patients with DKA or hypoglycemia (RBS less than 70 mg dl)

Sponsors & Collaborators

• Ain Shams University: lead

Study Sites (1)

Hanaa El Gendy

Cairo, Ain Shams University Specialized Hospital, Egypt

Location

MeSH Terms

Interventions

Observation

Intervention Hierarchy (Ancestors)

Methods; Investigative Techniques

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: December 6, 2019
• First Posted: December 12, 2019
• Study Start: March 15, 2016
• Primary Completion: October 20, 2017
• Study Completion: November 12, 2017
• Last Updated: February 4, 2021

Record last verified: 2021-02

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)