Prospective Randomized Observer Blinded Single Center Study Comparing 90-day Functional Outcome in Patients Who Received Intravenous Propofol Infusion Versus Inhalational Sevoflurane for General Anesthesia During Mechanical Thrombectomy in Patients Who Suffered From Acute Ischemic Stroke

NCT07001267 | Recruiting

• 1 other identifier: STUDY00161241
• Study Type: interventional
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

This study is being done to compare outcomes after surgery for individuals who receive anesthesia through by inhaling medication and individuals who receive anesthesia intravenously by needle when experiencing treatment for their stroke. Currently very little is known about the outcomes for patients when comparing these two techniques of providing anesthesia during surgery. This study will provide information regarding outcomes that will help health care providers decide which technique will be better for patients

Conditions

Acute Ischemic Stroke Patients

Keywords

Inhalation anesthesia; Intravenous anesthesia

Outcome Measures

Primary Outcomes (1)

• Functional Independence at 90 days

  The primary end point is functional independence at 90 days evaluated with the modified Rankin Scale (mRS). We plan to compare the functional recovery in 90 days in patients undergoing inhalational versus intravenous general anesthesia during mechanical thrombectomy using the modified Rankin score (mRS) in patients who suffered an acute ischemic stroke. (The mRS assesses a patient's functional independence or dependence after a stroke. Scores range from 0 (no symptoms) to 6 (death), with 0-2 indicating functional independence and 3-5 indicating dependence. A separate category of 6 is often added for patients who have died)

  From enrollment to 90 days after treatment

Secondary Outcomes (2)

• Comparison of National Institutes of Health Stroke Scale (NIHSS) score

  From enrollment to 90 days after treatment

• Thrombolysis in Cerebral Infarction (TICI) score

  From enrollment to 90 days after treatment

Study Arms (2)

inhalational sevoflurane

ACTIVE COMPARATOR

When treated for acute ischemic stroke, patient will receive inhalation sevoflurane as anesthesia

Procedure: Anesthesia drugs during the surgery

intravenous propofol infusion

ACTIVE COMPARATOR

When treated for acute ischemic stroke, patient will receive intravenous propofol infusion as anesthesia

Procedure: Anesthesia drugs during the surgery

Interventions

Anesthesia drugs during the surgery PROCEDURE

During treatment for acute ischemic stroke, patients will be given either inhalation or intravenous anesthesia.

inhalational sevoflurane; intravenous propofol infusion

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• \>18 years Acute ischemic stroke requiring endovascular treatment.

You may not qualify if:

• \<18 years
• Pregnant patients
• Patients with malignant hyperthermia
• Allergies or any contraindications to either inhalational or intravenous agents
• Patients already on intravenous anesthetic infusions
• Prisoners
• Students and employees

Sponsors & Collaborators

• University of Kansas Medical Center: lead

Study Sites (1)

University of Kansas Medical Center

Kansas City, Kansas, 66160, United States

RECRUITING

Study Officials

• Arun George, MD

  University of Kansas Medical Center

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Arun George, MD

CONTACT

913-588-6670; ageorge9@kumc.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: May 23, 2025
• First Posted: June 3, 2025
• Study Start: June 4, 2025
• Primary Completion (Estimated): May 31, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: March 12, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)