Dual Arterial Phase Liver CT in Patients With Suspected Portal Hypertension

NCT04195971 | Unknown DMC

• 1 other identifier: SNUH-2019-2587
• Study Type: interventional
• Target: 69
• Locations: 1 country
• Sites: 1

Brief Summary

Patients with liver cirrhosis is at risk of developing HCC. To diagnose or detect HCC at CT/MRI, optimal late arterial phase (LAP) acquisition is critical to capture the tumor. For LAP acquisition, bolus-tracking is often used at CT. In patients with portal hypertension, however, bolus-tracking occasionally capture early arterial phase which may be related with slow portomesenteric flow. In this study, we obtain dual arterial phase in patients with suspected portal hypertension and determine whether this protocol (dual arterial phase) would provide higher incidence of LAP acquisition than single arterial phase acquisition.

Conditions

HCC; Cirrhosis, Liver

Keywords

CT

Outcome Measures

Primary Outcomes (1)

• Incidence of optimal late arterial phase acquisition

  incidences of optimal late arterial phase acquisition in 1st and 2nd acquisition of arterial phase in this protocol (dual arterial phase) CT.

  1 months after study completion

Study Arms (1)

Liver CT with dual arterial phase

EXPERIMENTAL

Diagnostic Test: Liver CT

Interventions

Liver CT DIAGNOSTIC_TEST

Liver CT with precontrast, dual arterial phase, portal venous phase, and delayed phase.

Liver CT with dual arterial phase

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Older than 20 years
• Liver cirrhosis diagnosed with characteristic imaging feature or histology
• Presence of portal hypertension sign (splenomegaly and varices)
• Scheduled for liver CT
• And signed informed consent

You may not qualify if:

• Relative or absolute contra-indication of contrast-enhanced CT

Sponsors & Collaborators

• Seoul National University Hospital: lead

Study Sites (1)

Seoul National University Hospital

Seoul, 03080, South Korea

Location

MeSH Terms

Conditions

Liver Cirrhosis

Condition Hierarchy (Ancestors)

Liver Diseases; Digestive System Diseases; Fibrosis; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Jeong Min Lee, MD

  Seoul National University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: December 10, 2019
• First Posted: December 12, 2019
• Study Start: December 26, 2019
• Primary Completion: September 21, 2020
• Study Completion: June 1, 2022
• Last Updated: March 17, 2021

Record last verified: 2021-03

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)