Mechanism and Outcome of Acute Ischemic Stroke in Cancer Patients

NCT04195048 | Completed

• 1 other identifier: Mansoura University Hospital 9
• Study Type: observational
• Target: 160
• Locations: 1 country
• Sites: 1

Brief Summary

Stroke is a part of circulatory diseases which are the primary cause of death in Egypt. It accounts 14% of all deaths thus ranks the 2nd after ischemic heart disease. Cancer accounts 9% of population mortality in Egypt. Nearly 108,600 Egyptians newly diagnosed with cancer each year. The interrelationship between stroke and cancer is complex. Cancer may directly or indirectly lead to stroke via: hypercoagulability, nonbacterial thrombotic endocarditis (NBTE), direct tumor compression of blood vessels or treatment-related effects which potentiate stroke. The risk of ischemic stroke after chemotherapy is largely increased by the use of certain types of chemotherapy not only by cancer histologic type. Brain infarction usually a subsequent complication appears sometimes shortly after chemotherapy. Chronic radiation vasculopathy that affects medium and large intra- and extra-cranial arteries is characterized by increasing rates of hemodynamic significant stenosis with time after radiotherapy. The study aims to clarify the relation between cancer and its treatment with ischemic stroke by discussing the different mechanisms by which a vascular insult happen causing neurological deficit. The study provides more information about cancer patients with higher risk to develop ischemic stroke more than other patients by identifying co morbidities and dosage of cancer treatment that causes cerebrovascular insults.

Conditions

Ischemic Stroke; Cancer

Keywords

Ischemic Stroke, Cancer

Outcome Measures

Primary Outcomes (1)

• Modified Rankin Scale

  The modified Rankin Scale (mRS) is a commonly used scale for measuring the degree of disability or dependence in the daily activities of people who have suffered a stroke or other causes of neurological disability. It has become the most widely used clinical outcome measure for stroke clinical trials.

  6 months

Study Arms (2)

Cancer patients with acute ischemic stroke

Eighty patients previously or currently suffering from manifest cancer on or not on cancer treatment who developed stroke

Other: Risk factors

Control patients with acute ischemic stroke without cancer

Eighty patients with acute ischemic stroke without cancer

Other: Risk factors

Interventions

Risk factors OTHER

Risk factors: modifiable and unmodifiable risk factors

Cancer patients with acute ischemic stroke; Control patients with acute ischemic stroke without cancer

Eligibility Criteria

• Age: 25 Years - 89 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

* Retrospective study was conducted on patients diagnosed with cancer receiving chemotherapy or radiotherapy to evaluate the relation between cancer or cancer therapies and ischemic stroke development. * Patients had been recruited from the oncology center, nuclear medicine department and neurology department in Mansoura University and private centers.

You may qualify if:

• patients previously or currently suffering from manifest cancer on or not on cancer treatment who developed stroke
• control patient with ischemic storke without cancer

You may not qualify if:

• Patients developed cerebrovascular insults prior to the onset of cancer
• Cancer patients with symptoms mimic stroke.
• Cancer patients with focal neurological deficit due to direct effect of malignant tumor.
• Patients missed their follow up.
• Patients with traditional cerebrovascular risk factors such as (hypertension, hyperlipidemia, diabetes and atrial fibrillation) prior to cancer diagnosis.

Sponsors & Collaborators

• Mansoura University Hospital: lead

Study Sites (1)

Mansoura University Hospital

Al Mansurah, Dakahlia Governorate, 35516, Egypt

Location

MeSH Terms

Conditions

Ischemic Stroke; Neoplasms

Interventions

Risk Factors

Condition Hierarchy (Ancestors)

Stroke; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Risk; Probability; Statistics as Topic; Epidemiologic Methods; Investigative Techniques; Causality; Epidemiologic Factors; Quality of Health Care; Health Care Quality, Access, and Evaluation; Health Care Evaluation Mechanisms; Public Health; Environment and Public Health

Study Officials

• Esmael M Ahmed, MD

  Assistant Prof of Neurology

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Prof of Neurology

Study Record Dates

• First Submitted: December 9, 2019
• First Posted: December 11, 2019
• Study Start: November 1, 2018
• Primary Completion: October 1, 2019
• Study Completion: December 1, 2019
• Last Updated: December 11, 2019

Record last verified: 2019-12

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)