Prolonged Vasospasm in Subarachnoid Hemorrhage

NCT04193124 | Completed DMC

• 1 other identifier: HEC
• Study Type: observational
• Target: 109
• Locations: 0 countries
• Sites: N/A

Brief Summary

The prevalence and clinical implications of prolonged cerebral vasospasm in patients with subarachnoid hemorrhage are unknown.

Conditions

Subarachnoid Hemorrhage; Vasospasm, Intracranial

Keywords

Subarachnoid Hemorrhage; Vasospasm, Intracranial; Transcranial doppler

Outcome Measures

Primary Outcomes (2)

• Clinical implication

  Presence or not of neurological symptoms related to intracranial vasospasm (delayed cerebral ischemia)

  1 month

• Gravity of vasospasm by transcranial doppler

  Mild, moderate and severe according to Aaslid scale

  1 month

Secondary Outcomes (1)

• Mortality assessment

  six monts

Other Outcomes (1)

• Neurological recovery

  six monts

Study Arms (1)

Prolonged vasospasm

Adult patients with a diagnosis of subarcnoid hemorrhage CT scan or presence of blood in the cerebrospinal fluid were incorporated. Patients with vasospasm were followed daily with transcranial doppler. Prolonged vasospasm was defined for patients who persisted with vasospasm after day 21 of cerebral bleeding.

Diagnostic Test: transcranial doppler.

Interventions

transcranial doppler. DIAGNOSTIC_TEST

Daily monitoring of transcranial doppler until the disappearance of the intracranial vasosparm

Prolonged vasospasm

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with subarachnoid hemorrhage and vasospasm

Sponsors & Collaborators

• Hospital El Cruce: lead

Related Publications (4)

• Harders AG, Gilsbach JM. Time course of blood velocity changes related to vasospasm in the circle of Willis measured by transcranial Doppler ultrasound. J Neurosurg. 1987 May;66(5):718-28. doi: 10.3171/jns.1987.66.5.0718.

  PMID: 3553456 RESULT

• MASPES PE, MARINI G. Intracranial arterial spasm related to supraclinoid ruptured aneurysms. Acta Neurochir (Wien). 1962 Dec 12;10:630-8. doi: 10.1007/BF01406192. No abstract available.

  PMID: 13933363 RESULT

• Yamaguchi M, Bun T, Kuwahara T, Kitamura S. Very late-onset symptomatic cerebral vasospasm caused by a large residual aneurysmal subarachnoid hematoma--case report. Neurol Med Chir (Tokyo). 1999 Sep;39(9):677-80. doi: 10.2176/nmc.39.677.

  PMID: 10563118 RESULT

• Muller M, Schwerdtfeger K, Zieroth S. Assessment of middle cerebral artery diameter after aneurysmal subarachnoid hemorrhage by transcranial color-coded duplex sonography. Eur J Ultrasound. 2000 Mar;11(1):15-9. doi: 10.1016/s0929-8266(99)00066-x.

  PMID: 10717509 RESULT

MeSH Terms

Conditions

Subarachnoid Hemorrhage; Vasospasm, Intracranial

Interventions

Ultrasonography, Doppler, Transcranial

Condition Hierarchy (Ancestors)

Intracranial Hemorrhages; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Echoencephalography; Neuroradiography; Neuroimaging; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Radiography; Ultrasonography; Ultrasonography, Doppler; Diagnostic Techniques, Neurological; Investigative Techniques

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Target Duration: 6 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of Intensive Care Unit at Hospital El Cruce

Study Record Dates

• First Submitted: December 6, 2019
• First Posted: December 10, 2019
• Study Start: April 1, 2015
• Primary Completion: January 1, 2019
• Study Completion: December 1, 2019
• Last Updated: December 10, 2019

Record last verified: 2019-12

Data Sharing

• IPD Sharing: Will not share