Interactions of Brain Regions in Visuomotor Adaptation
Functional Interaction of Thalamus, Basal Ganglia, and the Cerebellum in Visuomotor Adaptation
1 other identifier
interventional
39
1 country
1
Brief Summary
The purpose of this study is to better understand the roles the cerebellum, basal ganglia, and thalamus play in motor learning. Patients undergoing High Intensity Focused Ultrasound (HIFU) treatment will be receiving an ablation procedure to their thalamus as a part of their medical procedure. Participation in this study will include completing a behavioral task before and after the procedure to see how motor learning task performance differs with and without the thalamus. Similarly, patients undergoing Deep Brain Stimulation (DBS) treatment will have an electrode implanted in their thalamus as a part of their medical procedures. Participation in this study will include completing the motor learning task performance "on" and "off" thalamic electrical stimulation.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Apr 2019
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 18, 2019
CompletedFirst Submitted
Initial submission to the registry
November 17, 2019
CompletedFirst Posted
Study publicly available on registry
December 9, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 17, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
April 17, 2021
CompletedDecember 9, 2019
December 1, 2019
2 years
November 17, 2019
December 5, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Performance Error on Visuomotor Task
The visuomotor task has practice, baseline, and experimental trials. Performance on the task will be compared between groups (HIFU treatment and DBS treatment) before and after treatment.
baseline, a week after HIFU treatment, several weeks after DBS implantation
Study Arms (2)
High Intensity Focused Ultrasound
EXPERIMENTALPatients receiving high intensity focused ultrasound as a treatment will be asked to complete the behavioral task pre and post their treatment.
Deep Brain Stimulation
EXPERIMENTALPatients receiving deep brain stimulation as a treatment will be asked to complete the behavioral task while their DBS electrode is "on" and "off".
Interventions
Patients will be asked to complete the behavioral assessment before and after their HIFU treatment or "on" and "off" their DBS treatment.
Eligibility Criteria
You may qualify if:
- Be a patient receiving either high intensity focused ultrasound treatment or deep brain stimulation treatment for Tremor
- Able to provide informed consent and complete study procedures
- Must speak English
- Age 18-85
You may not qualify if:
- Unable to provide consent or complete study procedures
- Women who self-report pregnancy
- Patients who are currently incarcerated
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Virginia
Charlottesville, Virginia, 22903, United States
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- OTHER
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 17, 2019
First Posted
December 9, 2019
Study Start
April 18, 2019
Primary Completion
April 17, 2021
Study Completion
April 17, 2021
Last Updated
December 9, 2019
Record last verified: 2019-12