Incidence, Risk Factors, Predictors and Survival for Neurological Complications After Liver Transplantation

NCT04188717 | Completed

• 1 other identifier: ILBS - Liver Transplant-2
• Study Type: observational
• Target: 253
• Locations: 0 countries
• Sites: N/A

Brief Summary

Liver transplantation is the definitive treatment in patients with chronic liver disease. Neurological complications (NC) occur commonly after liver transplantation. The investigators aim to evaluate the incidence, risk factors and predictors of neurological complications in both living donor and deceased donor transplantation done in the hospital. Between January 2011 to December 2016, 253 liver transplant recipients were recruited for this study. The investigators recorded the incidence of neurological complications, their median time of onset, their relationship with etiology of chronic liver disease, and the risk factors for the complications. The investigators also studied the relationship of neurological complications with duration of hospital and ICU stay, and survival. Using multivariate forward regression analysis , the investigators developed a scoring system for prediction of neurological complications in liver transplantation.

Conditions

Liver Transplant; Complications; Neurologic Complication; Postoperative Complications

Keywords

liver transplantation; neurological complications; postoperative complications

Outcome Measures

Primary Outcomes (2)

• Neurological complications

  type of neurological complication

  90 days

• Mortality

  mortality due to any cause

  90 days

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients who underwent liver transplant surgery for the specified time period were included in the study.

You may qualify if:

• patients undergoing liver transplant surgery
• years

You may not qualify if:

• pregnant patients
• Acute Liver Failure, Acute on Chronic Liver Failure

Sponsors & Collaborators

• Institute of Liver and Biliary Sciences, India: lead

MeSH Terms

Conditions

Postoperative Complications

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Karthik T Ponnappan, DM

  ILBS

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 28, 2019
• First Posted: December 6, 2019
• Study Start: January 1, 2010
• Primary Completion: December 31, 2016
• Study Completion: January 1, 2017
• Last Updated: December 10, 2019

Record last verified: 2019-11