Lung Ultrasound as a Point of Care Test for Living Donor Liver Transplant Recipients.

NCT04413695 | Unknown DMC

• 1 other identifier: ILBSIndia 2
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Liver transplant is now a standard treatment for end-stage liver disease patients. Pulmonary complications are common in the perioperative period and are associated with adverse outcomes. This includes atelectasis, pneumothorax, pleural effusion, pulmonary edema, and collapse. Risk factors for the same are extensive surgery, transfusion of blood products, fluid overload, hemodynamic instability, coagulation abnormalities, renal dysfunction, and reperfusion syndrome. CXR with clinical judgment plays a key role in diagnosing pulmonary complications. However diagnostic ability of CXR is limited and moreover it is associated with unnecessary radiation exposure. Recently, lung USG has come up as an easily available tool to detect peri-op pulmonary complications. The technique is very easy to perform, less time-consuming, and totally cost-effective. Moreover, it can be easily learned by clinicians with a standard level of ability to handle an ultrasound probe for abdominal scans. In the setting of geriatric and ICU patients, fragility and immobility have a strong impact on the quality of a chest radiograph. So, the routine application of lung USG in this setting may significantly improve the outcome. Multiple studies have suggested that Lung USG is superior to CXR in diagnosing these lung conditions. Hence, this study aims to compare the lung ultrasound with CXR in detecting perioperative pulmonary complications in patients undergoing live donor liver transplantation.

Conditions

Liver Transplant; Complications

Keywords

liver transplant; lung ultrasound; chest x ray

Outcome Measures

Primary Outcomes (1)

• Comparison of day of appearance of pulmonary complications on ultrasound and chest Xray

  Comparison of day of appearance of pulmonary complications on ultrasound and chest Xray

  till post operative seventh day

Secondary Outcomes (2)

• Incidence and types of postoperative pulmonary complications after live donor related liver transplant (LDLT)

  First post-operative seven days

• Correlation of lung ultrasound score with clinically relevant perioperative pulmonary complications and length of icu stay

  First post-operative seven days

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

End stage liver disease patients

You may qualify if:

• Age 18 to 65yrs All end stage liver disease patients undergoing live donor liver transplantation

You may not qualify if:

• Patients not giving consent for enrollment Any structural cardiac condition Dead donor liver transplant

Sponsors & Collaborators

• Institute of Liver and Biliary Sciences, India: lead

Study Sites (1)

Gaurav Sindwani

New Delhi, National Capital Territory of Delhi, 110070, India

RECRUITING

Related Publications (6)

• Feltracco P, Carollo C, Barbieri S, Pettenuzzo T, Ori C. Early respiratory complications after liver transplantation. World J Gastroenterol. 2013 Dec 28;19(48):9271-81. doi: 10.3748/wjg.v19.i48.9271.

  PMID: 24409054 BACKGROUND

• Ruchonnet-Metrailler I, Blanchon S, Luthold S, Wildhaber BE, Rimensberger PC, Barazzone-Argiroffo C, Mc Lin VA. Pulmonary complications after liver transplantation in children: risk factors and impact on early post-operative morbidity. Pediatr Transplant. 2018 Jul 17:e13243. doi: 10.1111/petr.13243. Online ahead of print.

  PMID: 30019517 BACKGROUND

• Tierney DM, Boland LL, Overgaard JD, Huelster JS, Jorgenson A, Normington JP, Melamed RR. Pulmonary ultrasound scoring system for intubated critically ill patients and its association with clinical metrics and mortality: A prospective cohort study. J Clin Ultrasound. 2018 Jan;46(1):14-22. doi: 10.1002/jcu.22526. Epub 2017 Oct 6.

  PMID: 28984373 BACKGROUND

• Zhao Z, Jiang L, Xi X, Jiang Q, Zhu B, Wang M, Xing J, Zhang D. Prognostic value of extravascular lung water assessed with lung ultrasound score by chest sonography in patients with acute respiratory distress syndrome. BMC Pulm Med. 2015 Aug 23;15:98. doi: 10.1186/s12890-015-0091-2.

  PMID: 26298866 BACKGROUND

• Yin W, Zou T, Qin Y, Yang J, Li Y, Zeng X, Kang Y; Chinese Critical Ultrasound Study Group (CCUSG). Poor lung ultrasound score in shock patients admitted to the ICU is associated with worse outcome. BMC Pulm Med. 2019 Jan 3;19(1):1. doi: 10.1186/s12890-018-0755-9.

  PMID: 30606165 RESULT

• Soummer A, Perbet S, Brisson H, Arbelot C, Constantin JM, Lu Q, Rouby JJ; Lung Ultrasound Study Group. Ultrasound assessment of lung aeration loss during a successful weaning trial predicts postextubation distress*. Crit Care Med. 2012 Jul;40(7):2064-72. doi: 10.1097/CCM.0b013e31824e68ae.

  PMID: 22584759 RESULT

Study Officials

• gaurav sindwani, md

  ilbs

  STUDY CHAIR

Central Study Contacts

gaurav sindwani, md

CONTACT

08728089898; drsindwani25@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: May 30, 2020
• First Posted: June 4, 2020
• Study Start: November 11, 2019
• Primary Completion: September 25, 2021
• Study Completion: September 25, 2021
• Last Updated: October 5, 2021

Record last verified: 2021-10

Data Sharing

• IPD Sharing: Will not share

Locations

IN (1)