Scaling up Evidence Based MNCH Interventions : A Quasi Experimental Study Umeed e Nau (UeN) Project

NCT04184544 | Unknown

• 1 other identifier: 0979-3131
• Study Type: interventional
• Target: 5,000,000
• Locations: 1 country
• Sites: 1

Brief Summary

The Umeed-e-Nau (UeN) initiative aims to support the introduction, scale up, and further piloting of high quality and high impact interventions to improve Maternal, Newborn And Child Health (MNCH)in Pakistan by harnessing the potential of both public and private sectors, coupled with introduction of women and girls empowerment interventions. UeN has two major components: 1) Introducing proven effective MNCH interventions at scale in 8 rural districts of Pakistan, and 2) Generating evidence on innovative approaches to improve MNCH while included in public health programs in Pakistan. There are six trials that are being conducted to address different evidences gaps to improve maternal, newborn and child health in Pakistan. The protocols of the trials will be registered separately.

Conditions

Maternal Complication of Pregnancy; Newborn Morbidity; Perinatal Problems

Outcome Measures

Primary Outcomes (2)

• Perinatal deaths

  20% reduction in perinatal mortality

  three years

• case fatality rate

  30% reduction in Pneumonia and diarrhea case fatality in participating health facilities

  Three years

Study Arms (2)

Maternal and Newborn health districts

EXPERIMENTAL

Group one included maternal and newborn health districts. These districts are further divided into three sub groups. Sub group 1 will receive only interventions focusing on maternal health (1 district (Sangher)); sub group 2 will receive interventions focusing only on newborn health (1 district (Nasirabad)); sub group 3 will receive combined maternal and newborn interventions (two districts (, Lasbila and Badin).

Other: Improving of quality of care at health facility and outreach level

Child Health

EXPERIMENTAL

Group two will receive child health interventions focusing on the implementation of the global action plan for pneumonia and diarrhea (GAPPD \[4districts, Qamabar Shahdadkot Muzaffargarh, Rahim Yar Khan Jafferabad).

Other: Improving of quality of care at health facility and outreach level

Interventions

Improving of quality of care at health facility and outreach level OTHER

Community Mobilization and engagement; Use of DHIS data for decision making; Capacity building of health care workers and providers and other Community level and facility level interventions to improve MNCH outcomes

Child Health; Maternal and Newborn health districts

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• All women of reproductive age in the project areas
• All children under the age of five years

You may not qualify if:

• The subjects not residing in the project catchment population

Sponsors & Collaborators

• Aga Khan University: lead
• Bill and Melinda Gates Foundation: collaborator
• The Hospital for Sick Children: collaborator

Study Sites (1)

Aga Khan University

Karachi, Sindh, 47800, Pakistan

Location

Related Publications (2)

• Muhammad S, Memon ZA, Mian A, Wasan Y, Rizvi A, Ahmed I, Soofi S, Cousens S, Bhutta ZA. A cross-sectional analysis of the impact of lady health worker visits in the prenatal and postnatal period on the uptake of continuum of care interventions and childhood mortality in Pakistan. J Glob Health. 2025 Jun 2;15:04158. doi: 10.7189/jogh.15.04158.

  PMID: 40452336 DERIVED

• Memon ZA, Muhammad S, Soofi S, Khan N, Akseer N, Habib A, Bhutta Z. Effect and feasibility of district level scale up of maternal, newborn and child health interventions in Pakistan: a quasi-experimental study. BMJ Open. 2020 Jul 14;10(7):e036293. doi: 10.1136/bmjopen-2019-036293.

  PMID: 32665387 DERIVED

Study Officials

• Zulfiqar A Bhutta, PhD

  AKU

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor and Founding Director

Model Details: Implementation research to Scale up of evidence based interventions comprising four components 1) Designing of management protocol and revision of training curricula and Capacity building of outreach and facility based health care providers; 2) sustained supplies of essential drugs and commodities; 3) community engagement through Lady health worker program and 4) Health Management information data improvement and use of the data for decision making to improve provision and quality of services

Study Record Dates

• First Submitted: November 29, 2019
• First Posted: December 3, 2019
• Study Start: March 1, 2017
• Primary Completion: December 31, 2022
• Study Completion: June 30, 2023
• Last Updated: September 1, 2021

Record last verified: 2021-08

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)