Randomized Controlled Trial of Time-Restricted Feeding (TRF) in Acute Ischemic Stroke Patients

NCT04184076 | Unknown

• 1 other identifier: 201903100RINA
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Many preclinical studies have demonstrated the beneficial effects of intermittent fasting (IF) in a wide range of neurological and cardiovascular diseases. This pilot study aims to investigate the safety and compliance as well as efficacy of one specific IF intervention called time-restricted feeding (TRF; 16 hours fasting daily) in patients with acute ischemic stroke (AIS).

Conditions

Fasting

Keywords

fasting; safety; compliance; ischemic stroke; time restricted feeding

Outcome Measures

Primary Outcomes (1)

• The events of stroke in-evolution, stroke recurrence and hypoglycemia in acute ischemic stroke patients with time restricted fasting (TRF) or normal eating (NE)

  1. Stroke in-evolution is defined as an increase in the NIHSS score of ≥2 points compared to initial score or the lowest score during admission, excluding other attributable medical or systemic causes. 2. Stroke recurrence is defined as newly developed neurological deficit due to acute cerebrovascular insult during the study period. 3. Hypoglycemia event is defined as symptomatic hypoglycemia fulfilling the criteria of Whipple's triad as symptoms known or likely to be caused by hypoglycemia, a low plasma glucose (\< 60 mg/dl) measured at the time of the symptoms and relief of symptoms when the glucose is raised to normal

  4 weeks

Secondary Outcomes (2)

• 3 months functional outcome, defined as modified Rankin Scale (mRS) <=1 as good outcome

  3 months

• Diffusion tensor imaging on MRI at baseline and 3 months post stroke

  3 months

Study Arms (2)

Dietary counseling alone

NO INTERVENTION

1. Controls will be instructed to maintain their weight throughout the trial, and not to change their eating or physical activity habits. Controls will visit the research center on a weekly basis for weigh-ins. Body composition and metabolic disease risk variables will be assessed in control subjects every 12 weeks. 2. Subjects will complete a 3-d food record (2 regular day and 1 holiday) each week during the experiment. 3. The blood draws will be taken at approximately 11:00 am. The following analyzes will be measured in plasma samples: ketones, fasting glucose, fasting insulin, hemoglobin A1c, liver function, renal function, albumin, lipid profiles, MMP-9, IL-6, TNF-alpha, exosome markers (phospho-IRS1, phospho-Tau, Abeta1-42). Metabolomic and lipidomic analyses will be performed on the baseline and 3-month time point plasma samples.

Time-restricted feeding (TRF) with dietary counseling

EXPERIMENTAL

1. Subjects will be instructed to eat ad libitum from 10:00 to 18:00 h daily, and fast from 18:00 to 10:00 h daily. During the 8-h feeding window, there will be no restrictions on types or quantities of foods consumed. During the fasting period, subjects will be encouraged to drink plenty of water and will be permitted to consume energy-free beverages. 2. Subjects will complete a 3-d food record (2 regular day and 1 holiday) each week during the experiment. 3. The blood draws will be taken at approximately 11:00 am, especially prior to the first consumption of food by subjects in the TRF group. The following analyzes will be measured in plasma samples: ketones, fasting glucose, fasting insulin, hemoglobin A1c, liver function, renal function, albumin, lipid profiles, MMP-9, IL-6, TNF-alpha, exosome markers (phospho-IRS1, phospho-Tau, Abeta1-42). Metabolomic and lipidomic analyses will be performed on the baseline and 3-month time point plasma samples.

Behavioral: Time-restricted feeding (TRF) with dietary counseling

Interventions

Time-restricted feeding (TRF) with dietary counseling BEHAVIORAL

1. Subjects will be instructed to administer time-restricted feeding. 2. Subjects have to compete a 3-d food record, including 2 regular day and 1 holiday. At baseline, a dietitian will provide 15 min of instruction to each participant on how to complete the food records. Subjects will be asked to measure the volume of foods consumed with household measures. The timing of food intake will be also recorded. Food records will be collected each week during the experiment and will be reviewed by the dietitian for accuracy and completeness. A database for food content will be used to calculate the total daily intake of energy, fat, protein, carbohydrate, cholesterol, and fiber. All subjects will be asked to maintain their level of physical activity throughout the entire trial. 3. Blood withdraw will be performed prior to the first consumption of food and analyze some biochemistry data.

Time-restricted feeding (TRF) with dietary counseling

Eligibility Criteria

• Age: 20 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients with acute ischemic stroke onset within 10 days
• Age between 20-80 years.
• Mild stroke severity (NIH stroke scale ≤ 6).

You may not qualify if:

• Large hemispheric (\> 1/2 middle cerebral artery territory) or cerebellar (\>3 cm in diameter) infarct
• Receiving intravenous rt-PA (alteplase) or endovascular thrombectomy
• Severe stenosis (\> 50%) or occlusion of intra/extra cranial arteries corresponding to acute ischemic stroke territory.
• Body mass index ≤ 24.
• Active cancer.
• Diabetes mellitus (ex. HbA1C \> 7% or taking oral hypoglycemic agent or insulin)
• Active gastrointestinal bleeding.
• Active infection, concurrent steroid usage or specific endocrine disorders.
• Pre-stroke modified Rankin Scale \> 2
• Not willing to participate the trial.

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, 1010, Taiwan

Location

MeSH Terms

Conditions

Fasting; Patient Compliance; Ischemic Stroke; Intermittent Fasting

Condition Hierarchy (Ancestors)

Feeding Behavior; Behavior; Patient Acceptance of Health Care; Treatment Adherence and Compliance; Health Behavior; Stroke; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Central Study Contacts

Sung-Chun Tang, MD. PhD

CONTACT

886-9-23562357; sctang@ntuh.gov.tw

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 17, 2019
• First Posted: December 3, 2019
• Study Start: January 1, 2020
• Primary Completion: December 31, 2021
• Study Completion: December 31, 2022
• Last Updated: December 3, 2019

Record last verified: 2019-07

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)