Is There Any Correlation Between Respiratory Variation Ratios of Internal Jugular Vein and Inferior Vena Cava?

NCT04173741 | Completed Results

• 1 other identifier: GO 17/427
• Study Type: observational
• Target: 46
• Locations: 1 country
• Sites: 1

Brief Summary

Intravascular volume assesment is important for the management of the patients in the intensive care unit. Respiratory variation ratio of the inferior vena cava (IVC) can be determined by ultrasonography (USG) and is a useful tool for hemodynamic evaluation of the patient. Aim of this study is to search for correlation between respiratory variation ratios of the internal jugular vein (IJV) and the IVC before and after passive leg raise. Another aim of this study is to search for variability between ultrasonographic measurements of different doctors.

Conditions

Critically Ill

Keywords

Positive Pressure Ventilation; Fluid Responsiveness; Passive Leg Raise; Inferior Vena Cava; Internal Jugular Vein; Interobserver Variability; Ultrasound

Outcome Measures

Primary Outcomes (1)

• Ultrasonography (USG) Measurements

  Because of the medium-high interrater correlation between USG measurements of the physicians, statistical analysis were done with the mean of USG measurements of 3 doctors.

  through study completion, 3 days

Study Arms (2)

Leg Rise Position - 3 Minutes

Patients who stayed in passive leg rise position for 3 minutes

Other: USG measurement

Leg Rise Position - 1 Minute

Patients who stayed in passive leg rise position for 1 minute

Other: USG measurement

Interventions

USG measurement OTHER

IVC was visualized in the subxiphoid long axis by using convex probe (5-1 MHz). Diameters of IVC was measured 2 cm caudally to the junction of hepatic vein in M-mode. IJV diameter was measured in the short axis by using linear probe (12-5 MHz) and M-mode. IJV visualized in the junction of cricothyroid membrane level and midclavicular line. Maximum and minimum diameter values were measured in the M mode. Distensibility (maximum diameter - minimum diameter / minimum diameter) and collapsibility (maximum diameter - minimum diameter / maximum diameter) indices were calculated after USG measurements were done.

Leg Rise Position - 1 Minute; Leg Rise Position - 3 Minutes

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Mechanically ventilated patients in the intensive care unit over 18 years of age

You may qualify if:

• Mechanically ventilated
• Over 18 years of age

You may not qualify if:

• Infection in the site of measurement areas
• Surgical sutures in the site of measurement areas
• Intraabdominal hypertension
• Severe aortic regurgitation
• Lower extremity amputation

Sponsors & Collaborators

• Hacettepe University: lead

Study Sites (1)

Hacettepe University Hospital Anesthesiology Intensive Care Unit

Ankara, Turkey (Türkiye)

Location

Related Publications (4)

• Nakamura K, Tomida M, Ando T, Sen K, Inokuchi R, Kobayashi E, Nakajima S, Sakuma I, Yahagi N. Cardiac variation of inferior vena cava: new concept in the evaluation of intravascular blood volume. J Med Ultrason (2001). 2013 Jul;40(3):205-9. doi: 10.1007/s10396-013-0435-6. Epub 2013 Feb 27.

  PMID: 27277237 BACKGROUND

• Nakamura K, Qian K, Ando T, Inokuchi R, Doi K, Kobayashi E, Sakuma I, Nakajima S, Yahagi N. Cardiac Variation of Internal Jugular Vein for the Evaluation of Hemodynamics. Ultrasound Med Biol. 2016 Aug;42(8):1764-70. doi: 10.1016/j.ultrasmedbio.2016.03.003. Epub 2016 Apr 20.

  PMID: 27108039 BACKGROUND

• Akilli NB, Cander B, Dundar ZD, Koylu R. A new parameter for the diagnosis of hemorrhagic shock: jugular index. J Crit Care. 2012 Oct;27(5):530.e13-8. doi: 10.1016/j.jcrc.2012.01.011. Epub 2012 Mar 3.

  PMID: 22386226 BACKGROUND

• Preau S, Saulnier F, Dewavrin F, Durocher A, Chagnon JL. Passive leg raising is predictive of fluid responsiveness in spontaneously breathing patients with severe sepsis or acute pancreatitis. Crit Care Med. 2010 Mar;38(3):819-25. doi: 10.1097/CCM.0b013e3181c8fe7a.

  PMID: 20016380 BACKGROUND

MeSH Terms

Conditions

Critical Illness

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Results Point of Contact

• Title: Dr. Asli Melek
• Organization: Hacettepe University

aslimelek121@gmail.com

+905376636789

Study Officials

• Asli Melek

  Hacettepe University

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: November 16, 2019
• First Posted: November 22, 2019
• Study Start: January 5, 2018
• Primary Completion: December 1, 2019
• Study Completion: December 1, 2019
• Last Updated: August 31, 2020
• Results First Posted: August 31, 2020

Record last verified: 2020-08

Locations

TU (1)