NCT04173312

Brief Summary

Efficacy of using continuous infusion of local anesthetic for post operative pain control following laparotomy.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
120

participants targeted

Target at P25-P50 for phase_3

Timeline
Completed

Started Jan 2021

Typical duration for phase_3

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

November 20, 2019

Completed
1 day until next milestone

First Posted

Study publicly available on registry

November 21, 2019

Completed
1.1 years until next milestone

Study Start

First participant enrolled

January 4, 2021

Completed
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2023

Completed
11 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2023

Completed
Last Updated

February 23, 2022

Status Verified

February 1, 2022

Enrollment Period

2 years

First QC Date

November 20, 2019

Last Update Submit

February 22, 2022

Conditions

Keywords

local anestheticcontinuous infusionpain control

Outcome Measures

Primary Outcomes (1)

  • Self Reported Pain

    Patient reported pain rating on the Visual Analog Scale (VAS) for Pain. Pain intensity is rated on a scale of 0 to 100. It is anchored by 0 for no pain and 100 for worst pain ever.

    5 days

Study Arms (2)

Infused analgesic

ACTIVE COMPARATOR

Patients will be assigned to receive local anesthetic through continuous infusion by pump.

Combination Product: Bupivacaine infusion

Infused saline

PLACEBO COMPARATOR

Patients will be assigned to receive saline through continuous infusion by pump.

Combination Product: Saline

Interventions

Bupivacaine infusionCOMBINATION_PRODUCT

Local systemic Infusion of anesthetic

Infused analgesic
SalineCOMBINATION_PRODUCT

Local systemic infusion of saline

Infused saline

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • \- Patients scheduled for elective laparotomy

You may not qualify if:

  • Emergency laparotomy
  • Pregnancy
  • Patients on chronic pain medication

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Ascension Genesys Hospital

Grand Blanc, Michigan, 48439, United States

RECRUITING

MeSH Terms

Conditions

Agnosia

Interventions

Sodium Chloride

Condition Hierarchy (Ancestors)

Perceptual DisordersNeurobehavioral ManifestationsNeurologic ManifestationsNervous System DiseasesSigns and SymptomsPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

ChloridesHydrochloric AcidChlorine CompoundsInorganic ChemicalsSodium Compounds

Study Officials

  • Tarik Wasfie, MD

    Ascension Health

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Tarik Wasfie, MD

CONTACT

Kimberly Barber, PhD

CONTACT

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Masking Details
Infusion will be the same for both groups. One will have analgesic and one will have saline.
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: Randomized control trial
Sponsor Type
INDUSTRY
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principle Investigator

Study Record Dates

First Submitted

November 20, 2019

First Posted

November 21, 2019

Study Start

January 4, 2021

Primary Completion

January 1, 2023

Study Completion

December 1, 2023

Last Updated

February 23, 2022

Record last verified: 2022-02

Data Sharing

IPD Sharing
Will not share

Locations