The Association Between the Duration of Acute Kidney Injury and New-onset Chronic Kidney Disease After Cardiac or Thoracic Aortic Surgery

NCT04172103 | Completed DMC

• 1 other identifier: 1909-115-1066
• Study Type: observational
• Target: 2,009
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators aimed to evaluate the association between the duration and stage of acute kidney injury (AKI) and the development of chronic kidney disease during postoperative three years in patients undergoing cardiac or thoracic aortic surgery.

Conditions

Acute Kidney Injury; Chronic Kidney Disease, Stage 3; Chronic Kidney Disease, Stage 5; Cardiac Surgery; Thoracic Aortic Surgery

Keywords

acute kidney injury; chronic kidney disease; cardiac surgery; thoracic aortic surgery

Outcome Measures

Primary Outcomes (1)

• new-onset chronic kidney disease stage 3 or higher or mortality

  development of new-onset chronic kidney disease stage 3 or higher or all-cause mortality developed during 3 years after surgery. The new-onset chronic kidney disease was defined by at least two estimated Glomerular Filtration Rate values \<60 ml/min/1.73 m2 separated by an interval of at least three months.

  during 3 years after surgery

Secondary Outcomes (17)

• new-onset chronic kidney disease stage 3 or higher or mortality

  during 1 year after surgery

• new-onset chronic kidney disease stage 3 or higher or mortality

  during 2 years after surgery

• Length of postoperative hospital stay

  during one month after surgery

• Length of postoperative intensive care unit stay

  during one month after surgery

• intra-aortic balloon pulsation insertion

  during surgery and postoperative one week

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

A retrospective cohort of the adult patients who underwent cardiac or thoracic aortic surgery under cardiopulmonary bypass at Seoul National University Hospital between 2008 and 2017

You may qualify if:

• Adult patients who underwent cardiac or thoracic aortic surgery under cardiopulmonary bypass at Seoul National University Hospital between 2008 and 2017

You may not qualify if:

• Those with off-pump coronary artery bypass
• Missing baseline serum creatinine
• Missing postoperative serum creatinine values of more than three among seven postoperative days
• Preoperative baseline chronic kidney disease with estimated glomerular filtration rate \<60 ml/min/1.73m2

Sponsors & Collaborators

• Seoul National University Hospital: lead

Study Sites (1)

Seoul National University Hospital

Seoul, 03080, South Korea

Location

Related Publications (2)

• Wang Y, Bellomo R. Cardiac surgery-associated acute kidney injury: risk factors, pathophysiology and treatment. Nat Rev Nephrol. 2017 Nov;13(11):697-711. doi: 10.1038/nrneph.2017.119. Epub 2017 Sep 4.

  PMID: 28869251 BACKGROUND

• Chawla LS, Eggers PW, Star RA, Kimmel PL. Acute kidney injury and chronic kidney disease as interconnected syndromes. N Engl J Med. 2014 Jul 3;371(1):58-66. doi: 10.1056/NEJMra1214243. No abstract available.

  PMID: 24988558 BACKGROUND

Related Links

• Statistical analysis plan

MeSH Terms

Conditions

Acute Kidney Injury; Renal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Won Ho Kim, MD, PhD

  Associate Professor

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 19, 2019
• First Posted: November 21, 2019
• Study Start: November 19, 2019
• Primary Completion: December 1, 2020
• Study Completion: December 1, 2020
• Last Updated: October 22, 2021

Record last verified: 2021-10

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)