Brief Summary

This study aims to determine the most effective strategy of reducing sedentary behavior to improve health. Specifically, we aim to answer the following questions: (a) To determine if there is a significant difference in acute post-prandial glucose response between continuous sitting and two intermittent standing regimes (high frequency, low duration breaks (HFLD) and low frequency, high duration breaks (LFHD)). We hypothesize that intermittent standing (combined HFLD breaks and LFHD breaks regimes) will result in lower overall acute post-prandial glucose compared to continuous sitting. (b) To determine if there is a significant difference in acute post-prandial glucose response between two strategies to reduce sitting with standing (HFLD standing breaks vs. LFHD standing breaks). We hypothesize that the HFLD breaks condition will elicit lower acute post-prandial glucose level compared to the LFHD breaks condition. All eligible participants will be consented and subjected to all three study conditions: (i) Uninterrupted sitting, (ii) HFLD breaks, and (iii) LFHD breaks. The order at which participants were subjected to these conditions will be randomly determined and each condition were performed a week apart. Standardized meals (breakfast and lunch) will be provided during each lab visit and participants will be then be asked to perform their usual work activity using a sit-stand workstation in the lab. Depending on their assigned condition, the participants will be prompted to stand or sit for a given period of time. A continuous glucose monitor will be used to measure glucose response to the intervention while an activPAL device will be used to make sure that participants are compliant with the study protocol.

Trial Health

On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment

participants targeted

Target at below P25 for not_applicable

Timeline

Completed

Started Aug 2018

Geographic Reach

1 country

1 active site

Status

completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

11 months study duration

Study Start

First participant enrolled

August 1, 2018

Completed

11 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 14, 2019

Completed

Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 14, 2019

Completed

5 months until next milestone

First Submitted

Initial submission to the registry

October 28, 2019

Completed

2 days until next milestone

First Posted

Study publicly available on registry

October 30, 2019

Completed

Last Updated

October 30, 2019

Status Verified

October 1, 2019

Enrollment Period

11 months

First QC Date

October 28, 2019

Last Update Submit

October 28, 2019

Conditions

Pre Diabetes Postprandial Hyperglycemia

Keywords

Interrupting sittingContinuous glucose monitroingPattern of sitting breaks

Outcome Measures

Primary Outcomes (3)

Postprandial glucose incremental area under the curve (iAUC)
iAUC will be calculated using the trapezoidal method.
post breakfast (3.5 hrs), post lunch (3.5 hrs), and total lab time (7 hrs)
Mean postprandial glucose
post breakfast (3.5 hrs), post lunch (3.5 hrs), and total lab time (7 hrs)
Glucose variability (mean amplitude glycemic excursions)
total lab time (7 hrs)

Secondary Outcomes (1)

Physical and Emotional feeling states
total lab time (7 hrs)