Mechanisms Underlying Spoken Language Production
1 other identifier
interventional
36
1 country
1
Brief Summary
Most of us take being able to communicate for granted. Anomia (word finding problems) after stroke can cause profound frustration and anxiety for patients and families. Some people recover; many don't. \~ 250,000 people in the UK have chronic speech and language problems post-stroke. This project will investigate how treatment for these people might be improved. The brain's speech areas can be stimulated using transcranial direct current stimulation (tDCS). The kit is simple; a battery powering electrodes placed on the scalp. Healthy people who had tDCS while naming pictures could find words quicker and their speech areas responded more efficiently. How it affects aphasic stroke patients' brain function is unknown.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Nov 2017
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 24, 2016
CompletedStudy Start
First participant enrolled
November 30, 2017
CompletedFirst Posted
Study publicly available on registry
October 24, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 30, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
January 30, 2022
CompletedMay 11, 2023
May 1, 2023
4.2 years
October 24, 2016
May 10, 2023
Conditions
Outcome Measures
Primary Outcomes (1)
Change in Naming Speed
change in Tailor-made object naming test,
change from baseline to 20 minutes during and 20 minutes post tDCS intervention
Secondary Outcomes (1)
Higher accuracy in naming
change from baseline to 20 minutes during and 20 minutes post tDCS intervention
Study Arms (2)
Real tDCS
EXPERIMENTALfMRI task plus anodal tDCS
Sham tDCS
SHAM COMPARATORfMRI task plus sham tDCS
Interventions
Eligibility Criteria
You may qualify if:
- English native speakers
- Over the age of 18
- months or more after aphasic stroke
- Able to provide informed consent
You may not qualify if:
- Significant medical or psychiatric co-morbidity
- Clinical or neuroimaging evidence of significant multifocal cerebral disease
- Contraindications to tdcs
- Contraindications to MRI
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Institute of Cognitive Neuroscience, University College London
London, Greater London, WC1N 3AZ, United Kingdom
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Jennifer Crinion, Dr
University College, London
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor Jennifer Crinion
Study Record Dates
First Submitted
October 24, 2016
First Posted
October 24, 2019
Study Start
November 30, 2017
Primary Completion
January 30, 2022
Study Completion
January 30, 2022
Last Updated
May 11, 2023
Record last verified: 2023-05
Data Sharing
- IPD Sharing
- Will not share