Sedentary Behavior, Cardiovascular Function, and Sleep

NCT04137068 | Unknown

• 1 other identifier: STUDY00020458
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

This is an interventional study that will examine how sedentary behavior (decreased physical inactivity) over time affects cardiovascular health (i.e. heart rate and blood pressure) and sleep quality/duration.

Conditions

Sedentary Behavior; Cardiovascular Function; Sleep

Keywords

Physical Activity; Sleep; Sedentary; Cardiovascular

Outcome Measures

Primary Outcomes (10)

• Endothelial Function

  Investigators will measure endothelial function as flow-mediated dilation at baseline, and each hour of the 3-hour sitting trials.

  3 weeks

• Oxidative stress

  Oxidative stress will be measured using malondialdehyde adducts (MDA) from Ethylenediaminetetraacetic acid (EDTA) plasma.

  3 weeks

• Endothelin-1

  Endothelin 1 (ET-1) will be measured from Ethylenediaminetetraacetic acid (EDTA) plasma.

  3 weeks

• Heart rate

  During the weekly trials, heart rate will be measured as beats per minute while participants are in a seated position during the prolonged sitting period.

  3 weeks

• Blood pressure

  During the weekly trials, blood pressure will be measured as systolic over diastolic in a seated position in the dominant arm

  3 weeks

• 24-hour BP measurement

  Investigators will measure 24-hour ambulatory blood pressure monitoring (AMBP, Spacelabs, Inc) at baseline and for 24-h before each in-lab visit.

  3 weeks

• Sleep duration

  Sleep duration will be scored from the ActiGraph and correlated with the sleep and activity diary.

  3 weeks

• Sleep efficiency

  Sleep efficiency will be scored from the ActiGraph and correlated with the sleep and activity diary.

  3 weeks

• Activity

  Activity will be scored from the ActiGraph and correlated with the sleep and activity diary.

  3 weeks

• Activity Perception

  Activity perception will be measured before each prolonged sitting trial using an Activity Perception questionnaire (Perception of Current Activity Questionnaire). The questionnaire has 7 questions with answers ranging from 1 to 5. The range of scores is from 7 to 35, with 7 suggesting a strong negative perception of current activity, and 35 suggesting a strong positive perception of current activity.

  3 weeks

Study Arms (1)

Sedentary to Active

OTHER

Participants will visit the research laboratory for baseline measurements at visit 1 after wearing a pedometer for one week and maintaining their typical level of physical activity. After the baseline visit, participants will reduce their step count by more than half for two weeks. Participants will visit the laboratory once every week during the 2 week interventional period for a total of 3 visits.

Behavioral: Reduced Activity

Interventions

Reduced Activity BEHAVIORAL

Participants reduce their activity level to \<5,000 steps/day and \<50 % of baseline steps.

Also known as: Sedentary Behavior

Sedentary to Active

Eligibility Criteria

• Age: 20 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Ages 20-80y
• Lean and overweight (BMI 18.5-40 kg/m2)
• No acute, chronic, or debilitating medical conditions
• No prescription/non-prescription medications or drugs of abuse
• Limited weight training or intense exercise (swimming, CrossFit)
• Non-smoker
• Average level of daily physical activity (8,000-12,499 steps/day)
• Persons who fit all the above criteria and are suitable based on a medical history and health habits questionnaire, sleep profiling questionnaire, and electrocardiogram and clinical biochemical screening tests of blood and urine may be eligible to participate.

You may not qualify if:

• Persons with any acute, chronic, or debilitating medical condition except pre-hypertension and/or mild to moderate sleep apnea will be excluded.
• Persons with any symptoms of acute or active illness (e.g. fever, leukocytosis) will be excluded.
• Persons with a history of severe psychiatric illness or psychiatric disorders will be excluded.
• Persons with a history of regular night/or rotating shift work, or who have traveled more than three time zones during the one month prior to the study will be excluded.
• Pregnant persons, decisionally impaired adults, and prisoners will be excluded.

Sponsors & Collaborators

• Oregon Health and Science University: lead

Study Sites (1)

Oregon Institute of Occupational Health Sciences

Portland, Oregon, 97239, United States

RECRUITING

MeSH Terms

Conditions

Sedentary Behavior; Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Officials

• Saurabh Thosar, Dr.

  Oregon Institute of Occupational Health Sciences

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: October 15, 2019
• First Posted: October 23, 2019
• Study Start: November 13, 2019
• Primary Completion: March 31, 2023
• Study Completion: March 31, 2023
• Last Updated: August 5, 2022

Record last verified: 2022-08

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)