Sleep Duration and Cardiovascular Health

NCT04804124 | Recruiting

• 1 other identifier: 00021448
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

This is a cross-sectional study with an optional intervention that will examine how extreme sleep durations relate to cardiovascular health, physical activity, and sleep quality by studying three groups of participants: short sleepers (≤ 6 hrs), long sleepers (≥ 9 hrs), and average duration sleepers (7-8 hrs). The optional intervention asks participants to maintain an 8-hour per night regular sleep schedule for one week.

Conditions

Sleep; Cardiovascular Risk Factor

Keywords

cardiovascular; sleep duration; vascular endothelial function

Outcome Measures

Primary Outcomes (3)

• Vascular Endothelial Function

  Investigators will measure endothelial function as flow-mediated dilation.

  2 weeks

• Blood pressure

  Blood pressure (systolic and diastolic) will be measured in a supine position in the dominant arm.

  2 weeks

• Sleep duration

  Sleep duration will be scored from the ActiGraph and correlated with the sleep and activity diary.

  2 weeks

Study Arms (3)

Short Sleepers

EXPERIMENTAL

Reported nightly sleep time of ≤6 hours

Behavioral: Regularized Sleep Schedule

Long Sleepers

EXPERIMENTAL

Reported nightly sleep time of ≥9 hours

Behavioral: Regularized Sleep Schedule

Average Duration Sleepers

EXPERIMENTAL

Reported nightly sleep time of 7-8 hours

Behavioral: Regularized Sleep Schedule

Interventions

Regularized Sleep Schedule BEHAVIORAL

Participants may maintain a self-selected 8-hour per night sleep schedule as an optional intervention. Participants from any of the three groups may complete the intervention.

Average Duration Sleepers; Long Sleepers; Short Sleepers

Eligibility Criteria

• Age: 25 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Men and women ages 25-65y
• Lean and overweight (BMI 18.5-40 kg/m2)
• No acute, chronic, or debilitating medical conditions
• No prescription/non-prescription medications or drugs of abuse
• Current non-smoker (tobacco and marijuana)
• Persons who fit all the above criteria and are suitable based on a medical history and health habits questionnaire, and additional sleep and health profiling questionnaires may be eligible to participate.

You may not qualify if:

• Persons with any acute, chronic, or debilitating medical condition except pre-hypertension will be excluded.
• Persons with any symptoms of acute or active illness (e.g. fever, leukocytosis) will be excluded.
• Persons with a history of severe psychiatric illness or psychiatric disorders will be excluded.
• Persons with a history of regular night/or rotating shift work in the past year, or who have traveled more than three time zones during the one month prior to the study will be excluded.
• Pregnant women, decisionally impaired adults, and prisoners will be excluded.

Sponsors & Collaborators

• Oregon Health and Science University: lead

Study Sites (1)

Oregon Health and Science University

Portland, Oregon, 97239, United States

RECRUITING

Study Officials

• Saurabh S Thosar, PhD

  Oregon Health and Science University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Nicole Chaudhary, MPH

CONTACT

5034942064; burkeni@ohsu.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: March 10, 2021
• First Posted: March 18, 2021
• Study Start: June 9, 2021
• Primary Completion (Estimated): September 15, 2027
• Study Completion (Estimated): September 15, 2027
• Last Updated: August 4, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)