Influence of Trainning in Parkinson's Disease

NCT04135924 | Unknown DMC

• 1 other identifier: 031.819.852-52
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Parkinson's disease (PD) is a neurodegenerative disorder of the central nervous system (CNS), chronic and progressive that is associated with the loss of dopaminergic neurons in the compact part of the substantia nigra. These patients often show excessive fatigue and dyspnea with the progression of the disease, and the later onset of treatment, lower the tolerance of the patient to perform physical activities. Walking is one of the main limiting factors for a good quality of life. Therefore, gait training can promote individuals a better physical condition to recover their activities, as well as to maintain good posture, and reduce exacerbated flexion of the characteristic spine, preventing falls and various types of trauma. A proposed gait training is the Nordic walk, which, when using sticks to gain balance, stability and coordination, allows the individual to obtain better functional capacity, besides performing aerobic and stimulating activity. In addition to the gait training, this research proposes respiratory muscle training (TMR), using a linear resistor capable of promoting resistance and strength gain of the inspiratory musculature. TMR is a therapeutic modality consecrated in the maximal inspiratory and expiratory pressure gain, directly influencing the peripheral musculature, favoring the practice of physical activities, such as walking itself to possibly condition the patient to longevity and dignity to practice their ADLs with better quality of life, allowing delayed disease progression. In addition, the practice of these individuals submitted to walking and respiratory muscle training protocols can bring great benefits as regards their quality of life, and their perception of space, as well as their importance in the social environment. One form of evidence to qualify these aspects is the quality of life assessment scale in PDQ-39 Parkinson's Disease Patients, which contributes among other factors to the satisfaction and performance of the activity.

Conditions

Parkinson Disease

Keywords

Rehabilitation; Neurological disease

Outcome Measures

Primary Outcomes (2)

• Measurement of lipid peroxidation

  Oxigen-reactive species

  8 weeks

• Respiratory function

  spirometry variables analysis

  8 weeks

Study Arms (3)

walking nordic and respiratory training group

ACTIVE COMPARATOR

It will be composed of patients with clinical diagnosis of Parkinson's disease, who will be submitted to respiratory muscle training (TMR) associated with the Nordic walking(NC) training .

Other: Rehabilitation

walking nordic group

ACTIVE COMPARATOR

It will be composed of patients with clinical diagnosis of Parkinson's disease, who will only be submitted to Nordic walking training.

Other: Rehabilitation

respiratory training group

ACTIVE COMPARATOR

It will be composed of patients with clinical diagnosis of Parkinson's disease, who will only be submitted to respiratory muscle training protocol.

Other: Rehabilitation

Interventions

Rehabilitation OTHER

physical exercise and respiratory muscle training

respiratory training group; walking nordic and respiratory training group; walking nordic group

Eligibility Criteria

• Age: 55 Years - 75 Years
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• without cognitive impairment
• Mini Mental State Examination with scores above 23
• clinical diagnosis of Parkinson's disease in grade 2-3 on the scale modified Hoehn and Yarh

You may not qualify if:

• volunteers who present cognitive, auditory and visual alterations, that incapacitate them to carry out the proposed procedure
• carriers of Diabetes Mellitus and other metabolic diseases
• heart disease and uncontrolled hypertension
• ethyl alcohol
• smoker
• those hospitalized at least six months prior to the study
• as well as those who do not use the medication and the correct dosage prescribed by the physician
• individuals with osteomioarticular dysfunctions and neurological diseases
• restricted to wheelchairs

Sponsors & Collaborators

• Universidade Metodista de Piracicaba: lead
• Universidade do Estado do Pará: collaborator

Study Sites (1)

Universidade do Estado do Pará

Belém, Pará, 66055-490, Brazil

RECRUITING

Related Publications (6)

• Earhart GM, Falvo MJ. Parkinson disease and exercise. Compr Physiol. 2013 Apr;3(2):833-48. doi: 10.1002/cphy.c100047.

  PMID: 23720332 RESULT

• Hoehn MM, Yahr MD. Parkinsonism: onset, progression, and mortality. 1967. Neurology. 2001 Nov;57(10 Suppl 3):S11-26. No abstract available.

  PMID: 11775596 RESULT

• Reyes A, Castillo A, Castillo J, Cornejo I. The effects of respiratory muscle training on peak cough flow in patients with Parkinson's disease: a randomized controlled study. Clin Rehabil. 2018 Oct;32(10):1317-1327. doi: 10.1177/0269215518774832. Epub 2018 May 13.

  PMID: 29756459 RESULT

• Reyes A, Ziman M, Nosaka K. Respiratory muscle training for respiratory deficits in neurodegenerative disorders: a systematic review. Chest. 2013 May;143(5):1386-1394. doi: 10.1378/chest.12-1442.

  PMID: 23714850 RESULT

• Ernst M, Folkerts AK, Gollan R, Lieker E, Caro-Valenzuela J, Adams A, Cryns N, Monsef I, Dresen A, Roheger M, Eggers C, Skoetz N, Kalbe E. Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2024 Apr 8;4(4):CD013856. doi: 10.1002/14651858.CD013856.pub3.

  PMID: 38588457 DERIVED

• Ernst M, Folkerts AK, Gollan R, Lieker E, Caro-Valenzuela J, Adams A, Cryns N, Monsef I, Dresen A, Roheger M, Eggers C, Skoetz N, Kalbe E. Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2023 Jan 5;1(1):CD013856. doi: 10.1002/14651858.CD013856.pub2.

  PMID: 36602886 DERIVED

MeSH Terms

Conditions

Parkinson Disease; Nervous System Diseases

Interventions

Rehabilitation

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Intervention Hierarchy (Ancestors)

Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Health Services; Health Care Facilities Workforce and Services

Study Officials

• Lucas M Matos, graduated

  Universidade do Estado do Pará

  STUDY CHAIR

Central Study Contacts

Larissa S Rocha, Phd

CONTACT

+5591991209221; lari1980@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director of Human Movement Department

Model Details: randomized clinical trial

Study Record Dates

• First Submitted: March 28, 2019
• First Posted: October 23, 2019
• Study Start: April 1, 2019
• Primary Completion: December 1, 2019
• Study Completion: July 1, 2020
• Last Updated: October 23, 2019

Record last verified: 2019-10

Data Sharing

• IPD Sharing: Will not share

Locations

BR (1)