NCT04117139

Brief Summary

This study investigates the diagnostic value of PET/MRI for cervical lymph node metastases from head and neck squamous cell carcinomas.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
142

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Oct 2019

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2019

Completed
2 days until next milestone

First Submitted

Initial submission to the registry

October 3, 2019

Completed
4 days until next milestone

First Posted

Study publicly available on registry

October 7, 2019

Completed
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 30, 2021

Completed
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

September 30, 2022

Completed
Last Updated

October 8, 2019

Status Verified

October 1, 2019

Enrollment Period

2 years

First QC Date

October 3, 2019

Last Update Submit

October 4, 2019

Conditions

Keywords

Positron-Emission-Tomography/Magnetic Resonance ImagingPET/MRICancer staging

Outcome Measures

Primary Outcomes (1)

  • Diagnostic Accuracy of PET/MRI for Malignancy in Regional Lymph Nodes

    PET/MRI scans are compared to histology as the golden standard to determine the diagnostic accuracy of PET/MRI for malignancy in regional lymph nodes

    7-10 days

Secondary Outcomes (1)

  • Diagnostic Accuracy of PET/MRI for Extracapsular Lymph Node Spread

    7-10 days

Study Arms (1)

Study Group

OTHER

In addition to other standard imaging modalities in the fast track cancer program, included patients will have a PET/MRI done.

Diagnostic Test: PET/MRI

Interventions

PET/MRIDIAGNOSTIC_TEST

A PET/MRI of the Head and Neck region is done for all patients included in the project.

Also known as: 18F-FDG-PET/MRI, FDG-PET/MRI, PET/MR, PET-MR, Positron-Emission-Tomography/Magnetic Resonance Imaging
Study Group

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Patients either suspected of or with histologically verified:
  • Relapse of head and neck squamous cell cancer with involvement of regional lymph node(s)
  • Cervical lymph node metastasis with unknown primary tumor site
  • Oral cavity squamous cell carcinoma
  • Oropharyngeal squamous cell cancer planned for trans oral robotic surgery

You may not qualify if:

  • Patients who cannot have a PET/MRI performed for different reasons (allergy, claustrophobia, medical implants)
  • Patients who had surgery, infection or other inflammatory inducing conditions on the neck within the last 8 weeks

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of ORL - Head & Neck Surgery and Audiology, Odense University Hospital

Odense, 5000, Denmark

RECRUITING

MeSH Terms

Conditions

Squamous Cell Carcinoma of Head and NeckHead and Neck NeoplasmsLymphatic Metastasis

Interventions

Positron-Emission TomographyMagnetic Resonance Imaging

Condition Hierarchy (Ancestors)

Carcinoma, Squamous CellCarcinomaNeoplasms, Glandular and EpithelialNeoplasms by Histologic TypeNeoplasmsNeoplasms by SiteNeoplasm MetastasisNeoplastic ProcessesPathologic ProcessesPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Tomography, Emission-ComputedImage Interpretation, Computer-AssistedDiagnostic ImagingDiagnostic Techniques and ProceduresDiagnosisImage EnhancementPhotographyRadionuclide ImagingTomographyDiagnostic Techniques, Radioisotope

Study Officials

  • Chadi N. Abdel-Halim, M.D.

    Odense University Hospital

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Christian Godballe, Professor

CONTACT

Chadi N. Abdel-Halim, M.D.

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
DIAGNOSTIC
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Medical Doctor and Principal Investigator

Study Record Dates

First Submitted

October 3, 2019

First Posted

October 7, 2019

Study Start

October 1, 2019

Primary Completion

September 30, 2021

Study Completion

September 30, 2022

Last Updated

October 8, 2019

Record last verified: 2019-10

Data Sharing

IPD Sharing
Will not share

Locations