A Study of SHR-1210 in Combination With Carboplatin+Paclitaxel-albumin in Subjects With Resectable NSCLC

NCT04108013 | Unknown Phase 2

• 1 other identifier: XWh-NSCLC-NEO-IIT-SHR1210
• Study Type: interventional
• Target: 38
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study is a randomized, controlled, open-label, prospective, single-center phase II clinical study. Target population is patients with stage II and IIIA resectable non-small cell lung cancer who had not received systemic chemotherapy. Study objective is to evaluate the major pathologic response of SHR-1210 + carboplatin + paclitaxel-albumin in subjects with resectable non-small cell lung cancer. SHR-1210 is a humanized anti-PD1 IgG4 monoclonal antibody.

Conditions

Lung Cancer Stage II; PD-1 Antibody; Non-small Cell Lung Cancer

Outcome Measures

Primary Outcomes (1)

• Major pathologic response

  It is defined as residual tumors less than 10% after neoadjuvant chemotherapy.

  3.5 months

Secondary Outcomes (2)

• Objective Response Rate

  6.5 months

• Pathological complete response

  3.5 months

Study Arms (2)

SHR-1210+Carboplatin+Paclitaxel-albumin

EXPERIMENTAL

Subject will receive SHR-1210 200mg every 3 weeks, carboplatin AUC 5 on Day 1 of each 21 day, Paclitaxel-albumin 130mg/m2 on Day 1 and Day 8 of each 21 day, 2 cycles.

Drug: SHR-1210

Carboplatin+Paclitaxel-albumin

ACTIVE COMPARATOR

Subject will receive carboplatin AUC 5 on Day 1 of each 21 day, Paclitaxel-albumin 130mg/m2 on Day 1 and Day 8 of each 21 day, 2 cycles.

Drug: Carboplatin and Paclitaxel-albumin

Interventions

SHR-1210 DRUG

In the experimental group, 200mg SHR-1210 was given in the first day of each cycle, Carboplatin was given in the first day of each cycle, Paclitaxel-albumin was given in the first and eighth day of each cycle, with intravenous drip.

SHR-1210+Carboplatin+Paclitaxel-albumin

Carboplatin and Paclitaxel-albumin DRUG

In the control group, Carboplatin was given in the first day of each cycle, Paclitaxel-albumin was given in the first and eighth day of each cycle, with intravenous drip.

Carboplatin+Paclitaxel-albumin

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Male or female 18-70 years of age.
• ECOG performance status of 0 or 1.
• Life expectancy ≥ 12 weeks.
• Subjects are diagnosed with histologically or cytologically confirmed NSCLC.
• Subjects are diagnosed with resectable stage II, stage IIIA non-small cell lung cancer.
• Subjects enrolled must have measurable lesion(s) according to the RECIST 1.1 standard (the CT scan length of the tumor lesion \> 10 mm, the short diameter of CT scan of the lymph node lesions \> 15 mm).
• Subjects haven't received radiotherapy, chemotherapy, surgery and targeted therapy before admission.
• Subjects must have adequate pulmonary function for expected pneumonectomy.
• The main organ's function is normal and it should meet the following criteria:
• (1)Blood routine examination should be complied with (No blood transfusion, no use of hematopoietic factors and no use of drugs for correction within 14 days):
• a.ANC ≥ 1.5×109/L； b.HB ≥ 90 g/L； c.PLT ≥ 100×109/L；
• (2)Biochemical tests must meet the following criteria:
• TBIL ≤ 1.5ULN；
• ALT、AST≤ 2.5 ULN (If abnormal liver function is caused by liver metastasis, ALT、AST\< 5ULN;
• sCr≤1.5ULN，endogenous creatinine clearance rate≥50ml/min(Cockcroft-Gault formula);

You may not qualify if:

• Subjects have symptomatic central nervous system metastasis.
• Subjects have a history of any active autoimmune disease or autoimmune disease including but not limited to the following: interstitial pneumonia, uveitis, enteritis, hepatitis, pituitary inflammation, vasculitis, myocarditis, nephritis, hyperthyroidism, hypothyroidism which can be included after hormone replacement therapy; Subjects with childhood asthma have been completely alleviated and without any intervention or vitiligo in adulthood can be included. Subjects who need medical intervention with bronchodilators can not be included.
• Subjects with congenital or acquired immunodeficiency such as HIV infection, active hepatitis B (HBV DNA ≥ 500 IU/ml), hepatitis C (hepatitis C antibody is positive and HCV-RNA is higher than the lower detection limit of the analysis method) or co-infection with hepatitis B and hepatitis C.
• Subjects used immunosuppressive drugs excluding nasal spray and inhaled corticosteroids or systemic steroids at physiological doses(prednisolone≤10 mg/day or other corticosteroids of the same pharmacophysiological dose) within 14 days before the first dose.
• Subjects were vaccinated with live attenuated vaccine within 4 weeks before the first dose or during the study period.
• Subjects has taken last systemic cytotoxic or radiotherapy treatment in the past 4 weeks or subjects are currently using other antineoplastic drugs.
• Subjects suffered from other malignant tumors in the past three years.
• There is evidence that subjects have pulmonary fibrosis, interstitial pneumonia, pneumoconiosis, radiation pneumonia, drug-induced pneumonia and severe impairment of lung function.
• Subjects have uncontrollable hypertension (systolic pressure ≥ 140 mmHg or diastolic pressure ≥ 90 mmHg), despite patients have taken the best drug treatment;
• Subjects with grade II or above myocardial ischemia or myocardial infarction and poorly controlled arrhythmias (QTc interval \> 450 ms for males and QTc interval \< 470 ms for females). Subjects with grade III-IV cardiac insufficiency or with left ventricular ejection fraction (LVEF) less than 50% had myocardial infarction within 6 months before admission according to NYHA criteria. Subjects with grade II or above heart failure, uncontrolled angina, uncontrolled severe ventricular arrhythmias, clinically pericardial disease, acute ischemia or abnormal active conduction system.
• The subjects developed severe infection within 4 weeks before the first dose (such as: intravenous antibiotics, antifungal or antiviral drugs), or fever of unknown reason (\>38.5 °C) before the first dose or during the first screening period.
• History of allogeneic organ transplantation or allogeneic hematopoietic stem cell transplantation is known.
• Pregnant or lactating women; Fertile subjects who are unwilling or unable to take effective contraceptive measures
• It is known that subjects have allergic reaction, hypersensitivity reaction or intolerance to SHR-1210, paclitaxel-albumin or its excipients.
• Investigators believe that there is any situation that could damage the subjects or cause the subjects to fail to meet or perform the research requirements.

Sponsors & Collaborators

• Xuanwu Hospital, Beijing: lead

MeSH Terms

Conditions

Lung Neoplasms; Carcinoma, Non-Small-Cell Lung

Interventions

camrelizumab; Carboplatin

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases; Carcinoma, Bronchogenic; Bronchial Neoplasms

Intervention Hierarchy (Ancestors)

Coordination Complexes; Organic Chemicals

Study Officials

• Yi Zhang, Doctor

  Xuanwu Hospital, Beijing

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Shuyang Yao

CONTACT

15810401496; yaoshuyang@163.com

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Chief physician

Study Record Dates

• First Submitted: September 26, 2019
• First Posted: September 27, 2019
• Study Start: October 8, 2019
• Primary Completion: July 31, 2021
• Study Completion: July 31, 2021
• Last Updated: September 27, 2019

Record last verified: 2019-09

Data Sharing

• IPD Sharing: Will not share