Bayis Ilh Tus - A Strong Breath: Prevalence and Contributors to COPD in First Nations Communities in British Columbia

NCT04105088 | Recruiting

• 1 other identifier: ASB-2018
• Study Type: observational
• Target: 325
• Locations: 1 country
• Sites: 1

Brief Summary

Background. First Nations peoples in Canada carry an increased respiratory health burden compared to non-First Nations. However, there is little accurate information of how many First Nations people have COPD, especially in remote and rural areas. Goal \& Aims of the Study. The goal of this study is to estimate the burden of COPD in remote and rural First Nations communities. This project is a partnership between the University of British Columbia (UBC), Carrier Sekani Family Services (CSFS), and 13 First Nations communities in northern BC. Aim 1: Estimate the prevalence of COPD and the magnitude of underdiagnosis. Aim 2: Characterize the relationship between inhaled pollutants (from residential, occupational, and community/cultural sources) and: 1) symptoms; 2) airflow obstruction; and 3) health care utilization. Methodology. The investigators will recruit adults from randomly-selected households in 13 First Nations communities in northern BC. Detailed measurements of lung function, symptoms, self-reported exposure to lung irritants, air quality, and healthcare use will be collected. Expected Outcomes. This study will provide an accurate estimate of the prevalence of COPD and, using a culturally-relevant community-based research approach, will identify the contribution of risk factors to COPD in First Nations communities.

Conditions

Pulmonary Disease, Chronic Obstructive

Keywords

First Nations; Indigenous; Epidemiology; Risk Factors; Community-based Research

Outcome Measures

Primary Outcomes (3)

• forced expiratory volume, 1st second in litres

  pre- and post-bronchodilator FEV1 to determine reversibility of airflow obstruction

  measured at study recruitment

• forced vital capacity in litres

  pre- and post-bronchodilator measures of vital capacity for use in the diagnosis of COPD

  measured at study recruitment

• FEV1/FVC ratio

  pre- and post-bronchodilator measures of FEV1/FVC to confirm diagnosis of COPD (where the FEV1 to FVC \<0.70)

  measured at study recruitment

Study Arms (2)

Randomly-Sampled

Adults aged 30+ living in one of the First Nations communities whose household was randomly-sampled.

Walk-in Volunteers

Adults aged 30+ living in one of the First Nations communities who is a walk-in study volunteer, not randomly-sampled.

Eligibility Criteria

• Age: 30 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

We will recruit members of the participating First Nations communities, aged 30 years and older.

You may qualify if:

• years and older
• living in one of participating First Nations communities

You may not qualify if:

• confusion, dementia

Sponsors & Collaborators

• University of British Columbia: lead
• Carrier Sekani Family Services: collaborator

Study Sites (1)

13 individual First Nations in north-Central BC near Prince George, BC

Prince George, British Columbia, V2K5S3, Canada

RECRUITING

Related Publications (1)

• Turner J, Holyk T, Bartlett K, Rathburn B, Karlen B, Ervin F, Wilson J, Camp PG. "Bayis Ilh Tus - a strong breath" a community-based research project to estimate the prevalence of chronic obstructive pulmonary disease in remote and rural first nations communities in Canada: research protocol. Int J Equity Health. 2020 Jul 24;19(1):123. doi: 10.1186/s12939-020-01240-1.

  PMID: 32709235 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

dust samples from residences and community buildings

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Pat G Camp, PhD

  University of British Columbia

  PRINCIPAL INVESTIGATOR

• Travis Holyk, PhD

  Carrier Sekani Family Services

  STUDY DIRECTOR

Central Study Contacts

Pat G Camp, PhD

CONTACT

604-806-9144; pat.camp@hli.ubc.ca

Travis Holyk, PhD

CONTACT

250-562-3591; travis@csfs.org

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: September 24, 2019
• First Posted: September 26, 2019
• Study Start: February 13, 2018
• Primary Completion: March 31, 2026
• Study Completion: March 31, 2026
• Last Updated: January 19, 2024

Record last verified: 2024-01

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)