A Study of SHR4010 in Patients With Hemodialysis

NCT04099927 | Completed Phase 1

• 1 other identifier: SHR0410-102
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

The study is being conducted to evaluate the safety and pharmacokinetics of SHR0410 in patients with hemodialysis.

Conditions

Pruritus

Outcome Measures

Primary Outcomes (1)

• Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability])

  Pre-dose to Day13

Secondary Outcomes (10)

• Assessment of PK parameter-Area under drug-time curve (AUC0-t)

  Pre-dose to Day 6

• Assessment of PK parameter-Area under drug-time curve (AUC0-∝)

  Pre-dose to Day 6

• Assessment of PK parameter-peak time (Tmax)

  Pre-dose to Day 6

• Assessment of PK parameter-peak concentration (Cmax)

  Pre-dose to Day 6

• Assessment of PK parameter-half-life (t1/2)

  Pre-dose to Day 6

Study Arms (1)

SHR0410

EXPERIMENTAL

Experimental: SHR0410 dose escalation.

Drug: SHR0410

Interventions

SHR0410 DRUG

SHR0410 monotherapy,given intravenously

Also known as: KOR agonist

SHR0410

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Able to understand the study procedures, the risks involved and obtain written informed consent before any study related activity;
• Male or female between the ages of 18 and 65 years, inclusive;
• A total body weight ≥ 50 kg;
• End stage of renal disease (ESRD) participants who have been on hemodialysis (including hemodiafiltration) for at least six months and are currently on hemodialysis (including hemodiafiltration) three times a week.
• Male subjects with a partner of childbearing potential must be willing to use a condom when sexually active, throughout the study period and for 28 days following last study drug dosing. Female subjects must be post-menopausal for at least 1 year, permanently sterilized (e.g., tubal occlusion, hysterectomy,bilateral salpingectomy) or, if of childbearing potential, must be willing to use a highly effective method of contraception throughout the study period and for 28 days following last study drug dosing, and enter the trial only after menstruation is confirmed..

You may not qualify if:

• Anticipated to receive a kidney transplant during the study;
• Known history of allergic reaction to opiates such as hives (Note: side effects related to the use of opioids such as constipation or nausea would not exclude the participants from the study);
• History of drug abuse in the past;
• Nicotine test positive;
• Alcohol breath test was positive;
• The average daily intake of alcohol in the three months before screening was more than 15 g (15 g alcohol equivalent to 450 ml beer or 150 ml wine or 50 ml low-alcohol liquor).
• Could not obey the unified dietary arrangements and avoid taking coffee or tea during the study period;
• Blood pressure of upper limbs in supine position was : systolic pressure \< 110 mmHg, diastolic pressure \< 70 mmHg or systolic pressure \> 180 mmHg, diastolic pressure \> 110 mmHg at screening or pre-dosing after confirmation in a repeat test;
• New York Heart Function Classification (NYHA) \> III in the screening stage, or abnormal electrocardiogram with clinical significance judged by researchers in the screening stage , including QTcF \> 480ms;
• Screening alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transferase \> 1.5 × ULN, or total bilirubin\> 1.5 × ULN.
• Positive at screening for human immunodeficiency virus (HIV) antibody, Hepatitis B surface antigen (HBsAg), or Hepatitis C virus (HCV) antibody.
• Undergone major surgery within 3 months prior to screening.
• Total blood loss ≥ 200 ml within 30 days prior to screening, excluding female bleeding during physiological period.
• Blood human chorionic gonadotropin (hCG) test was positive.
• Opioids were used within a week before screening, or opioids other than research drugs could not be avoided during the study period.

Sponsors & Collaborators

• Jiangsu HengRui Medicine Co., Ltd.: lead

Study Sites (1)

Zhongda Hospital Affiliated to Southeast University

Nanjing, Jiangsu, 210009, China

Location

MeSH Terms

Conditions

Pruritus

Condition Hierarchy (Ancestors)

Skin Diseases; Skin and Connective Tissue Diseases; Skin Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Jianjun Zou

  Jiangsu HengRui Medicine Co., Ltd.

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Model Details: SHR0410 monotherapy

Study Record Dates

• First Submitted: August 28, 2019
• First Posted: September 23, 2019
• Study Start: July 28, 2019
• Primary Completion: April 20, 2020
• Study Completion: June 15, 2020
• Last Updated: August 18, 2022

Record last verified: 2020-05

Locations

CN (1)