Timed Exercise Study
Investigating the Effects of Timed Exercise on Human Circadian Rhythms
1 other identifier
interventional
67
1 country
1
Brief Summary
The purpose of this study was to investigate the effect of timed exercise on human circadian rhythms. Subjects were randomized to 5 days of morning or evening treadmill exercise. A measure of internal circadian timing, or phase, was measured at baseline and following the exercise intervention. Change in circadian phase was compared between the morning and evening group.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Jun 2017
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 27, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 9, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
March 9, 2019
CompletedFirst Submitted
Initial submission to the registry
August 29, 2019
CompletedFirst Posted
Study publicly available on registry
September 20, 2019
CompletedSeptember 20, 2019
September 1, 2019
1.7 years
August 29, 2019
September 19, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Change in onset (time) of melatonin secretion
Difference in onset (time at which salivary melatonin exceeds threshhold; 4pg/mL) from baseline to completion of exercise intervention.
baseline and following completion of exercise intervention (approximately 5 days)
Study Arms (2)
Morning Exercise Group
EXPERIMENTALParticipants perform moderate exercise in the morning.
Evening Exercise Group
EXPERIMENTALParticipants perform moderate exercise in the evening.
Interventions
moderate intensity exercise (70% VO2 max) each morning for 5 days
moderate intensity exercise (70% VO2 max) each evening for 5 days
Eligibility Criteria
You may qualify if:
- BMI 18.5-40.0
- sedentary; \<=2 hrs structured exercise weekly
- medication free (other than birth control)
You may not qualify if:
- diagnosed conditions that would contraindicate safe participation in physical activity
- diagnosed psychiatric conditions
- night or rotating shift work 1-year prior to study
- travel across time zones within previous 4 weeks
- having children \<2 years of age
- smoking
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Julie Pendergastlead
Study Sites (1)
University of Kentucky
Lexington, Kentucky, 40536, United States
Related Publications (1)
Thomas JM, Kern PA, Bush HM, McQuerry KJ, Black WS, Clasey JL, Pendergast JS. Circadian rhythm phase shifts caused by timed exercise vary with chronotype. JCI Insight. 2020 Feb 13;5(3):e134270. doi: 10.1172/jci.insight.134270.
PMID: 31895695DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Julie Pendergast
University of Kentucky
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Assistant Professor
Study Record Dates
First Submitted
August 29, 2019
First Posted
September 20, 2019
Study Start
June 27, 2017
Primary Completion
March 9, 2019
Study Completion
March 9, 2019
Last Updated
September 20, 2019
Record last verified: 2019-09
Data Sharing
- IPD Sharing
- Will not share