NCT04093934

Brief Summary

This study aims to establish a sustainable programme whereby early childhood development activities are integrated into the routine activities of community clinics in rural Bangladesh for undernourished children by developing a cascade of training at national, district, Upazila (sub-district), and union level to train clinic staff.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
480

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jul 2022

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 18, 2019

Completed
1 month until next milestone

First Posted

Study publicly available on registry

September 18, 2019

Completed
2.8 years until next milestone

Study Start

First participant enrolled

July 1, 2022

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 30, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 30, 2022

Completed
Last Updated

April 13, 2022

Status Verified

January 1, 2022

Enrollment Period

6 months

First QC Date

August 18, 2019

Last Update Submit

April 12, 2022

Conditions

Keywords

Early childhood developmentPsychosociaal stimulationBayley testBangladeshUndernutritionStepped wedge designCluster randomized controlled trial

Outcome Measures

Primary Outcomes (2)

  • Cognitive function

    Cognitive Composite scores on Bayley Scales of Infant and Toddler Development-III test, measuring children's cognition aged 1-42 months, ranging from 55 to 145. Higher values represent better outcome.

    Through study completion, an average of 1 year

  • Language development

    Language Composite scores on Bayley Scales of Infant and Toddler Development-III test, measuring children's language aged 1-42 months, ranging from 47 to 153. Higher values represent better outcome.

    Through study completion, an average of 1 year

Secondary Outcomes (8)

  • Response to examiner

    Through study completion, an average of 1 year

  • Emotional Tone

    Through study completion, an average of 1 year

  • Cooperation with test procedure

    Through study completion, an average of 1 year

  • Vocalization

    Through study completion, an average of 1 year

  • Quality of home stimulation

    Through study completion, an average of 1 year

  • +3 more secondary outcomes

Study Arms (2)

Intervention

EXPERIMENTAL

Children in the intervention arm will receive sessions of psychosocial stimulation every two weeks at the community clinics for one year. The intervention includes songs, games, book and toy activities for undernourished children and nutritional and developmental messages for their mothers.

Behavioral: Psychosocial stimulation

Wait-listed control

NO INTERVENTION

The wait-listed controls will be only tested at baseline and after a year. Following completion of the 2nd test, they will be included in the study and receive the same intervention provided to children in the experimental arm.

Interventions

Children will receive fortnightly sessions of psychosocial stimulation and nutritional support for one year during the study period.

Also known as: Nutritional support
Intervention

Eligibility Criteria

Age6 Months - 24 Months
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • Moderately and severely malnourished children
  • Aged 6-24 mo
  • Both sexes
  • Mid-upper arm circumference (MUAC)\<12.5 cm
  • Parents agree to participate in the programme.

You may not qualify if:

  • Children with MUAC≥12.5 cm
  • Those whose parents do not consent to participate
  • Children with disability, multiple births or any congenital abnormality will be included in the intervention but excluded from the evaluation sample

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

International Centre for Diarrhoeal Disease Research, Bangladesh

Dhaka, 1212, Bangladesh

Location

Related Publications (1)

  • Tipu SMMU, Hossain SJ, Arifeen SE, Mehrin SF, Salveen NE, Kawsir M, Bhuiyan MSA, Shiraji S, Hasan MI, Tofail F, Hamadani JD. A sustainable organizational structure to integrate psycho-social stimulation programme into primary health care services in Bangladesh: protocol for a pragmatic cluster randomized controlled trial on scaling up early childhood development activities. BMC Psychol. 2025 May 19;13(1):525. doi: 10.1186/s40359-025-02795-w.

MeSH Terms

Conditions

Malnutrition

Interventions

Nutritional Support

Condition Hierarchy (Ancestors)

Nutrition DisordersNutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Nutrition TherapyTherapeutics

Study Officials

  • Jena D Hamadani, PhD

    International Centre for Diarrhoeal Disease Research, Bangladesh

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Jena D Hamadani, PhD

CONTACT

Fahmida Tofail, PhD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: 'stepped wedge design'
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 18, 2019

First Posted

September 18, 2019

Study Start

July 1, 2022

Primary Completion

December 30, 2022

Study Completion

December 30, 2022

Last Updated

April 13, 2022

Record last verified: 2022-01

Data Sharing

IPD Sharing
Will not share

The data will not be shared with other researchers in its present form, however, de-identified data may be shared with other researchers if they come up with any novel idea for new analysis.

Locations