Impact of Neuropsychological Alteration of Patients With Eating Disorders

NCT04091477 | Completed

• 1 other identifier: RECHMPL19_0436
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Eating disorders are multifactorial disorders currently conceptualized in a biopsychosocial model, but pathophysiology remains relatively unknown, and robust etiological models to guide treatment are therefore lacking. Different endophenotypes and neurocognitive vulnerability factors have been found in eating disorders including decision making abnormalities. The investigators hypothesize that decision making abnormalities are associated with a lower level of functioning and quality of life which could lead to social and interpersonal difficulties. The investigators also hypothesize that these anomalies are associated with a particular clinical profile (more restrictive profile, more hyperactivity, less insight on the disease and desire for care ...).

Conditions

Eating Disorder

Keywords

Anorexia nervosa; Bulimia; Binge eating disorders; Neuropsychology; neurocognition; Daily functioning

Outcome Measures

Primary Outcomes (1)

• Level of functional impairment assessed by the clinician with the FAST scale

  We aim to investigate the link between global functioning and decision making abnormalities of patients with eating disorder. The Functioning Assessment Short Test (FAST) is composed of 24 items assessing various dimensions of daily functionning. Each item is ranged from 0 (no difficulty) to 3 (major difficulty) like a likert scale. The FAST is subdivided in 6 subscales : Autonomy (from 0 to 12), Professional activity (from 0 to 15), Cognitive functioning (from 0 to 15), Finances (from 0 to 6), interpersonal relationships (from 0 to 18) and Hobbies (from 0 to 6). The total score is the sum of the 6 subscales from 0 to 72. A hight score reveal hight difficulties in daily functionning

  1 day

Secondary Outcomes (3)

• Decision making assessed by the Iowa Gambling Task

  1 day

• Level of cognitive flexibility assessed by the Brixton test

  1 day

• Level of central coherence assessed by the Rey Figure Test

  1 day

Eligibility Criteria

• Age: 15 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with eating disorder

You may qualify if:

• Patient with an eating disorder according to DSM-V criteria
• Patient aged from 15 to 65 years
• Patient who performs the day-hospital evaluation
• Patient affiliated to a French social security system
• Patient able to understand the nature, the aim and the methodology of the study For minor one of the legal guardians gave his consent

You may not qualify if:

• Patient in an unstable somatic state (eg severe metabolic disorder making impossible or unreliable neuropsychological assessments)
• Patient's refusal to participate
• Patient protected by law (guardianship or curatorship)
• Pregnant or nursing women. A dosage of βHCG will be performed to ensure the absence of pregnancy.

Sponsors & Collaborators

• University Hospital, Montpellier: lead
• INSERM 1061-Montpellier: collaborator

Study Sites (1)

Uhmontpellier

Montpellier, 34295, France

Location

MeSH Terms

Conditions

Feeding and Eating Disorders; Anorexia Nervosa; Bulimia; Binge-Eating Disorder

Condition Hierarchy (Ancestors)

Signs and Symptoms, Digestive; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Mental Disorders; Hyperphagia

Study Officials

• Sébastien Guillaume, PhD

  University Hospital, Montpellier

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 13, 2019
• First Posted: September 16, 2019
• Study Start: October 1, 2019
• Primary Completion: December 1, 2019
• Study Completion: December 30, 2019
• Last Updated: March 11, 2020

Record last verified: 2019-09

Locations

FR (1)