Biological Risk Factors for Onset of Binge Eating and Compensatory Behaviors
1 other identifier
observational
88
1 country
1
Brief Summary
The purpose of this proposed project is to test whether several biological factors (such as elevated brain reward region and attention region response to high-calorie foods, weaker inhibitory region response to high-calorie foods, habitual caloric deprivation, and elevated limbic region responsivity) increase the risk of problematic eating (bingeing and purging) in female adolescents.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Aug 2017
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 3, 2017
CompletedFirst Submitted
Initial submission to the registry
September 21, 2018
CompletedFirst Posted
Study publicly available on registry
September 27, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
October 1, 2021
CompletedNovember 3, 2021
November 1, 2021
4.2 years
September 21, 2018
November 2, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Change in binge eating behaviors using the EDDI
Eating Disorder Diagnostic Interview (EDDI)
6 months, 1 year, 2 year, and 3 year follow-up
Change in compensatory behaviors using the EDDI
Eating Disorder Diagnostic Interview (EDDI)
6 months, 1 year, 2 year, and 3 year follow-up
Study Arms (2)
High Risk Group
Parental history of eating pathology
Low Risk Group
No parental history of eating pathology
Eligibility Criteria
Community sample
You may qualify if:
- Female
- Aged 13-16 years
You may not qualify if:
- Adolescents who report functional magnetic resonance imaging (fMRI) contraindications
- Current Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5) substance abuse disorder, eating disorder (ED), conduct disorder, attention deficit hyperactivity disorder (ADHD), or bipolar disorder
- Weekly or greater use of psychoactive drugs (e.g., analgesics, cocaine, marijuana)
- Serious medical complications (e.g., cancer, diabetes)
- History of head injury
- Relevant food allergies
- BMI \> 35
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Oregon Research Institute
Eugene, Oregon, 97403, United States
Related Publications (1)
Stice E, Yokum S, Rohde P, Cloud K, Desjardins CD. Comparing healthy adolescent females with and without parental history of eating pathology on neural responsivity to food and thin models and other potential risk factors. J Abnorm Psychol. 2021 Aug;130(6):608-619. doi: 10.1037/abn0000686.
PMID: 34553956DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Eric Stice, Ph.D.
Stanford University
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 21, 2018
First Posted
September 27, 2018
Study Start
August 3, 2017
Primary Completion
October 1, 2021
Study Completion
October 1, 2021
Last Updated
November 3, 2021
Record last verified: 2021-11