Biological Markers of Functional Effects of Physical Activity in an Elderly Population

NCT04080063 | Completed

• 1 other identifier: 19-PP-06
• Study Type: interventional
• Target: 92
• Locations: 1 country
• Sites: 1

Brief Summary

Circulating biomarkers are promising tools for the early diagnosis of aging-associated pathologies. Inflammation and immunity are associated with the risk of sarcopenia and frailty in elderly patients. The investigators investigate the effect of an adapted physical activity program on the metabolism and function of circulating immune cells and miRNA in frail and non-frail elderly subjects. Induced immune changes are analyzed together with that of motor abilities and of frailty status.

Conditions

Fragility

Outcome Measures

Primary Outcomes (2)

• analysis of phenotype of circulating T cells

  Measurement of T cell populations determined by flow cytometry (FACS) Different antibodies will be used to caracterize different sub-population (CD3+ ; CD4+ ; CD8+ ; T-regulator ; T-helper 1 and 17)

  change from baseline physical activity at 3 months

• Concentration of mRNAs related to PPARβ/δ gene expression

  Analysis of mRNAs from blood sample related to PPARβ/δ gene expression by Luminex technology

  change from baseline physical activity at 3 months

Study Arms (1)

adapted physical activity

EXPERIMENTAL

a personalized care will be offered in terms of adapted physical activity

Other: adapted physical activity

Interventions

adapted physical activity OTHER

The study begins with an evaluation of physical strenght and cognitive and psychometric assessment.Then, a personalized care will be offered in terms of adapted physical activity. The evaluation protocol will be performed again to measure the impact of physical activity three months after the first assessment.

adapted physical activity

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• Patient who signed the informed consent
• Older men and women ≥ 65 years
• Can walk without technical help

You may not qualify if:

• Patient with protective measures (guardianship, curatorship, and deprivation of liberty).
• Patient with a neurological problem
• No affiliation to a social security scheme (beneficiary or assignee)
• Knee and / or hip prosthesis
• Orthopedic complications with repercussions on walking activities

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Nice: lead

Study Sites (1)

CHU de Nice

Nice, 06000, France

Location

Study Officials

• Olivier GUERIN

  guerin.o@chu-nice.fr

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 26, 2019
• First Posted: September 6, 2019
• Study Start: November 4, 2019
• Primary Completion: February 21, 2022
• Study Completion: February 21, 2022
• Last Updated: November 18, 2023

Record last verified: 2023-11

Locations

FR (1)