Stroke Survival in Municipalities: Impact of Geographic Proximity to First- and Second-degree Relatives

NCT04072120 | Unknown DMC

• 1 other identifier: NorStrokeSurvival
• Study Type: observational
• Target: 7,400,000
• Locations: 1 country
• Sites: 1

Brief Summary

Our key objective will be to investigate if geographic proximity to first- and second-degree relatives has an influence on post-acute stroke survival and use of health and social services. We will also model and map spatial variation in stroke and cardiovascular disease (CVD) incidence and mortality and see if some of the variation is due to spatial clustering of familial risk. The study will use innovative approaches to large-scale registry and survey data and statistical analysis on the full Norwegian population. We will integrate multigenerational and geographical information. This will enable us to assess key determinants on stroke survival and use of health and social care at municipality level.

Conditions

Stroke

Keywords

Stroke; Post-acute stroke; Geographical proximity; Family; Relatives; Survival analysis

Outcome Measures

Primary Outcomes (3)

• R1- Mortality

  Mortality of Norwegian citizens aged 45 and above 1.1.1994 - 31.12. 2009

  Mortality follow-up from 1.1.1994 to 31.12.2014

• R2- Mortality

  Mortality of all Norwegians born in the period 1 January 1940 to 31 December 1959 who survived to 1991

  Mortality follow-up from 1991-2014.

• R3- Stroke events

  Norwegian citizens aged 45 and above 1.1.2016

  Stroke events registered in the Patient registry after 2016, (possibly until 2019)

Study Arms (3)

R1

1. Norwegian citizens aged 45 and above 1.1.1994 - 31.12. 2009 registered in the FS-data during this period. 2. Sub-sample those attending a cardiovascular health survey who later developed stroke.

R2

All Norwegians born in the period 1 January 1940 to 31 December 1959 who survived to 1991.

R3

Norwegian citizens aged 45 and above 1.1.2016.

Eligibility Criteria

• Age: 45 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

1. All Norwegian residents in the period from 1960 to 2017 (n=7,4 mill), including all births and deaths(from the Cause of Death Registry) occurring in this population from 1960 onwards. 2. The Multigenerational Register in Statistics Norway covering family linkage on all individuals to their parents for all born after 1952 is included. 3. The Census from 1960, and from 1970 to 2011 4. Hospital data on hospital discharge from cardiovascular events among all Norwegians from 1992.

You may qualify if:

• Norwegian citizens aged 45 and above 1.1.1994 - 31.12. 2009 and had stroke events
• Those who attend a cardiovascular health survey who later developed stroke.
• All Norwegians born in the period 1 January 1940 to 31 December 1959 who survived to 1991
• Norwegian citizens aged 45 and above 1.1.2016 and had stroke events

Sponsors & Collaborators

• University of Oslo: lead
• Extrastiftelsen: collaborator
• The National Association for Public Health, Norway: collaborator

Study Sites (1)

Department of Community Medicine and Global Health,University of Oslo

Oslo, 0450, Norway

Location

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Øyvind Næss, MD, MSc, PhD

  Department of Community Medicine and Global Health, University of Oslo

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctoral Research Fellow

Study Record Dates

• First Submitted: August 22, 2019
• First Posted: August 28, 2019
• Study Start: August 15, 2019
• Primary Completion: August 14, 2022
• Study Completion: August 14, 2022
• Last Updated: May 15, 2020

Record last verified: 2020-05

Locations

NO (1)