Long-term Follow-up After Stroke (The LAST-long Trial)

NCT03859063 | Completed DMC

• 1 other identifier: 2018/1809
• Study Type: interventional
• Target: 301
• Locations: 1 country
• Sites: 4

Brief Summary

Despite the improved treatment of acute stroke over the past decades, those suffering from stroke still are at an increased risk of functional and cognitive decline in the long term. The most common consequences of stroke are functional impairments, cognitive impairments, depression and fatigue. These are also regarded as barriers to achieve optimal adherence to the guidelines regarding secondary prevention. The primary aim of this project is to evaluate the effectiveness of a multimodal individualized intervention to prevent functional decline in the long term after stroke.

Conditions

Stroke

Keywords

Rehabilitation; Cognition; Physical Fitness; Case Managers; Secondary prevention

Outcome Measures

Primary Outcomes (1)

• Modified Rankin Scale (mRS)

  mRS is an ordinal scale ranging from 0 to 6 measuring global function. 0 denotes no symptoms while 6 denotes death.

  18 months

Secondary Outcomes (76)

• Modified Rankin Scale (mRS)

  6 months

• Modified Rankin Scale (mRS)

  12 months

• Barthel Index

  6 months

• Barthel Index

  12 months

• Barthel Index

  18 months

Study Arms (2)

Intervention

EXPERIMENTAL

Regular follow up by a community based stroke coordinator

Behavioral: Intervention

Control

ACTIVE COMPARATOR

Usual care

Behavioral: Control

Interventions

Intervention BEHAVIORAL

Participants randomized to the intervention arm will be followed with monthly meetings by a stroke coordinator for 18 months. The stroke coordinator will assess the patients risk factors within the domains of physical function, cognitive function, social function, medication and lifestyle factors and make a treatment plan targeting the individual needs for further follow-up.

Intervention

Control BEHAVIORAL

Community based follow-up as usual

Also known as: Usual care

Control

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosis of first ever or recurrent stroke (ischemic stroke or hemorrhage)
• mRS \< 5
• Living in Trondheim, Skedsmo or Lørenskog municipality
• Less than 10 points on Short Physical Performance Battery (SPPB) OR less than 26 points on Montreal Cognitive Assessment (MoCA) OR more than 27 points on the 7 item version of the Fatigue Severity Scale (FSS-7) OR more than 7 points on the depression or anxiety items on Hospital Anxiety and Depression Scale (HADS) OR reduced hand function (i.e. fails on Motor Assessment Scale - Advanced arm- and hand function, item 3)
• Able to understand Norwegian
• Able and willing to sign informed consent.

You may not qualify if:

• Life expectancy \< 12 months
• Other serious diseases, judged by the medical doctor to make it difficult to comply with the intervention (i.e. serious neurological diseases or drug abuse).

Sponsors & Collaborators

• Norwegian University of Science and Technology: lead
• St. Olavs Hospital: collaborator
• University Hospital, Akershus: collaborator
• Asker & Baerum Hospital: collaborator
• Alesund Hospital: collaborator

Study Sites (4)

Ålesund Hospital

Ålesund, 6017, Norway

Location

Akershus University Hospital

Lørenskog, Norway

Location

Vestre Viken Bærum Hospital

Sandvika, Norway

Location

St Olavs Hospital Stroke Unit

Trondheim, Norway

Location

Related Publications (3)

• Askim T, Langlo SR, Bergh E, Dohl O, Ellekjaer H, Hokstad A, Ihle-Hansen H, Indredavik B, Lydersen S, Luzum G, Seljeseth Y, Skandsen T, Saltvedt I, Thommessen B. A multimodal individualized long-term intervention to prevent functional decline after stroke (LAST-long): a single blinded randomised controlled trial. Lancet Reg Health Eur. 2025 Nov 13;61:101531. doi: 10.1016/j.lanepe.2025.101531. eCollection 2026 Feb.

  PMID: 41323876 DERIVED

• Askim T, Hokstad A, Bergh E, Dohl O, Ellekjaer H, Ihle-Hansen H, Indredavik B, Leer ASM, Lydersen S, Saltvedt I, Seljeseth Y, Thommessen B. Multimodal individualised intervention to prevent functional decline after stroke: protocol of a randomised controlled trial on long-term follow-up after stroke (LAST-long). BMJ Open. 2023 May 10;13(5):e069656. doi: 10.1136/bmjopen-2022-069656.

  PMID: 37164457 DERIVED

• Gibson E, Koh CL, Eames S, Bennett S, Scott AM, Hoffmann TC. Occupational therapy for cognitive impairment in stroke patients. Cochrane Database Syst Rev. 2022 Mar 29;3(3):CD006430. doi: 10.1002/14651858.CD006430.pub3.

  PMID: 35349186 DERIVED

MeSH Terms

Conditions

Stroke

Interventions

Methods

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Investigative Techniques

Study Officials

• Jorunn Helbostad, phd prof

  Norwegian University for Science and Technology

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: Single-blinded. The investigator and outcomes assessor will be blinded to group allocation.
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: A two armed parallel group randomized controlled trial

Study Record Dates

• First Submitted: February 11, 2019
• First Posted: March 1, 2019
• Study Start: April 11, 2019
• Primary Completion: September 30, 2024
• Study Completion: December 31, 2024
• Last Updated: September 16, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

NO (4)