Thiol/Disulphide Homeostasis and Albumin in Vertigo

NCT04070664 | Completed

• 1 other identifier: medybu137
• Study Type: observational
• Target: 55
• Locations: 1 country
• Sites: 1

Brief Summary

Vertigo is a common complaint in the Emergency Department (ED). The differential diagnosis of central and peripheral vertigo is a difficult issue that directly affects mortality. Magnetic resonance imaging (MRI) is the preferred diagnostic tool, but may not be suitable in all patients due to logistic and economic conditions. In this study, the investigators evaluated the role of thiol/disulfide homeostasis (TDH) parameters and ischemia modified albumin (IMA) levels to assist in the value of being used instead of MRI.

Conditions

Vertigo, Peripheral; Vertigo, Central Origin; Oxidative Stress; Diagnosis

Keywords

Vertigo; Central vertigo; Peripheral vertigo; Thiol/disulfide homeostasis; Ischemia modified albumin; Differential diagnosis

Outcome Measures

Primary Outcomes (2)

• Oxidative stress

  Thiol/disulphide homeostasis

  6 months

• Ischemic status

  Ischemia modified albumin

  6 months

Study Arms (2)

Central vertigo

Patients without any pathology on MRI were included in the peripheral vertigo group, and patients whose scans demonstrated acute ischemic infarct in the posterior fossa were included in the central vertigo group.

Peripheral vertigo

Patients without any pathology on MRI were included in the peripheral vertigo group, and patients whose scans demonstrated acute ischemic infarct in the posterior fossa were included in the central vertigo group.

Eligibility Criteria

• Age: 51 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who were admitted to the ED with acute onset vertigo of less than 24 hours and who underwent brain MRI for differential diagnosis of peripheral or central vertigo

You may qualify if:

• Patients with complaint of vertigo
• Patients over18 years of age

You may not qualify if:

• Patients contraindicated for MRI due to metal prosthesis or claustrophobia
• Patients under 18 years of age
• Pregnant patients
• Tobacco users
• Patients exhibiting significant neurological signs or symptoms such as motor or sensory neurologic deficit, speech disorders, unconsciousness, or seizure
• Patients found to have any type of lesion such as a hematoma, mass, cyst, aneurysm, arteriovenous malformation, etc. other than ischemic infarcts on MRI
• Patients with an ischemic lesion other than posterior fossa lesions
• Patients with any type of infection, including upper respiratory tract and ear infections
• Patients previously diagnosed with peripheral vertigo
• Patients where the cause of lightheadedness was blood pressure disorders, cardiac ischemic and arrhythmic disorders, thromboembolic diseases, metabolic disorders, trauma, etc. rather than central and peripheral vertigo.

Sponsors & Collaborators

• Ankara City Hospital Bilkent: lead
• Ankara Training and Research Hospital: collaborator

Study Sites (1)

Ankara Yıldırım Beyazıt University, School of Medicine, Department of Emergency Medicine

Ankara, Çankaya, 06800, Turkey (Türkiye)

Location

Related Publications (3)

• Kartal AG, Yilmaz S, Yaka E, Pekdemir M, Sarisoy HT, Cekmen MB, Yuksel M. Diagnostic value of S100B protein in the differential diagnosis of acute vertigo in the emergency department. Acad Emerg Med. 2014 Jul;21(7):736-41. doi: 10.1111/acem.12420.

  PMID: 25125270 BACKGROUND

• Bektas H, Vural G, Gumusyayla S, Deniz O, Alisik M, Erel O. Dynamic thiol-disulfide homeostasis in acute ischemic stroke patients. Acta Neurol Belg. 2016 Dec;116(4):489-494. doi: 10.1007/s13760-016-0598-1. Epub 2016 Jan 18.

  PMID: 26782823 BACKGROUND

• Sahin E, Deveci I, Dinc ME, Ozker BY, Bicer C, Erel O. Oxidative Status in Patients with Benign Paroxysmal Positional Vertigo. J Int Adv Otol. 2018 Aug;14(2):299-303. doi: 10.5152/iao.2018.4756.

  PMID: 30256204 BACKGROUND

Biospecimen

Retention: NONE RETAINED

Venous blood samples

MeSH Terms

Conditions

Vertigo; Disease

Condition Hierarchy (Ancestors)

Vestibular Diseases; Labyrinth Diseases; Ear Diseases; Otorhinolaryngologic Diseases; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Pathologic Processes

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Assistant Professor

Study Record Dates

• First Submitted: August 22, 2019
• First Posted: August 28, 2019
• Study Start: July 1, 2018
• Primary Completion: December 31, 2018
• Study Completion: December 31, 2018
• Last Updated: August 28, 2019

Record last verified: 2019-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)