Relationship Between Heme Oxygenase 1 Enzyme Level and Coronary SYNTAX Score

NCT04070014 | Completed

• 1 other identifier: YeditepUH
• Study Type: observational
• Target: 159
• Locations: 1 country
• Sites: 1

Brief Summary

Aim of this study is to investigate the relationship between heme oxygenase-1 enzyme level and angiographically determined SYNTAX score in patients with suspected stable coronary artery disease. Consecutive patients who are deemed to undergo coronary angiography due to high pre test probability or evidence of cardiac ischemia in imaging studies will be included in the study. Patients with coronary artery bypass surgery history and severe comorbid illnesses such as active malignancy, chronic obstructive lung disease, stage 3-5 chronic renal failure will be excluded. Serum heme oxygenase levels will be measured by ELISA method and SYNTAX score will be calculated from coronary angiography.

Conditions

Coronary Artery Disease; Oxidative Stress

Outcome Measures

Primary Outcomes (1)

• Relationship between serum heme oxygenase-1 enzyme level and SYNTAX score

  Correlation between serum heme oxygenase levels (in pg/ml) and angiographically determined SYNTAX scores (no unit) will be determined statistically.

  3 months

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Consecutive patients from a single center with suspected stable coronary artery disease who are deemed to undergo coronary angiographic evaluation will be included in the study. Patients will be recruited in a non randomized fashion.

You may qualify if:

• Patients with suspected stable coronary artery disease who are deemed to undergo coronary angiographic evaluation

You may not qualify if:

• Patients with history of coronary bypass or other cardiac surgery
• Patients with acute coronary syndrome
• Patients with severe comorbid illnesses including active malignancies, stage 3-5 chronic renal failure, chronic obstructive lung disease
• Patients with clinically overt infectious or inflammatory diseases
• Patients taking medications that possibly interact with heme metabolism
• patients with hemoglobinopathies

Sponsors & Collaborators

• Yeditepe University Hospital: lead

Study Sites (1)

Yeditepe University Hospital

Istanbul, Turkey (Türkiye)

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Serum obtained from peripheral blood will be used.

MeSH Terms

Conditions

Coronary Artery Disease

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: August 22, 2019
• First Posted: August 28, 2019
• Study Start: October 1, 2019
• Primary Completion: November 25, 2019
• Study Completion: March 30, 2020
• Last Updated: June 22, 2020

Record last verified: 2020-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)