NCT04053114|Withdrawn
Study Stopped
Principal investigator left the investigational center and nobody took over.
MOLecular Characterization and Treatment of THYroid Carcinoma on Struma Ovarii
MOLTHYSO
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Principal investigator left the investigational center and nobody took over.
MOLTHYSO
Sponsor study identifier
Secondary identifiers
OTHER · Institut National des Données de Santé (INDS)
observational
0
1 country
1
Study Start
January 1, 2019
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
December 2020
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 2020
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Thyroid carcinoma on struma ovarii (TCSO) is a rare ovarian tumor, derivate from monodermic teratomas. It represents about 0.01% of overall ovarian tumours, and 5 to 10% of struma ovarii. The diagnosis is histologic and retrospective after pelvic surgery. Because of its rarity, the treatment of TCSO is not consensual and should be validated in multidisciplinary team involved in rare ovarian carcinoma. TCSO should be taken care of as a thyroid carcinoma, in case of relapse, with systemic treatment, as tyrosine kinase inhibitor (TKI), without any clinical trial proving this benefit. Indeed, molecular profiles and genomic expression is unknown, because of studies with few patients (less than 10) contrary to thyroid carcinomas with the TCGA genomic classification. The study purposes are the outcome of the patients after the first treatment and the comparison of the genomic profil in next generation sequencing (NGS) with TCGA thyroid carcinoma profile. Thus, the treatment could be tailored, confirming the same therapy as in thyroid carcinoma.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2020
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 1, 2019
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
July 4, 2019
Actual (reported)August 12, 2019
Actual (reported)December 2020
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
December 2020
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Treatment description
Description of the previous treatment for the TCSO (first treatment and relapse) in the retrospective cohort
Between first treatment and last follow up, assessed up to 100 months
Tissue samples
Next generation sequencing (NGS)
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
French women older than 18 years old with a TCSO registered in the French " Rare malignant gynecologic tumors " network from 2007 to 2017.
Institut Bergonié
Bordeaux, Aquitaine, 33076, France
Frozen or FFPE tumoral specimens suitable for DNA and RNA extraction.
Anne FLOQUET, MD
Institut Bergonié
0 participants (actual enrollment reported by the registry).
First Submitted
July 4, 2019
First Posted
August 12, 2019
Study Start
January 1, 2019
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Primary Completion
December 2020
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 2020
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
August 29, 2025
Record last verified: 2025-08
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Source: ClinicalTrials.gov.
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