NCT04047329

Brief Summary

This study examined the risk factors and the influence of the type of anesthetic used during transurethral resection of the prostate (TURP) on subsequent incidence of myocardial infarction (MI).

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
115,025

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 1998

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 1998

Completed
15 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2012

Completed
3.2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

March 22, 2016

Completed
3.3 years until next milestone

First Submitted

Initial submission to the registry

July 23, 2019

Completed
14 days until next milestone

First Posted

Study publicly available on registry

August 6, 2019

Completed
Last Updated

August 7, 2019

Status Verified

September 1, 2015

Enrollment Period

15 years

First QC Date

July 23, 2019

Last Update Submit

August 5, 2019

Conditions

AnesthesiaTransurethral Resection of Prostate SyndromeMyocardial Infarction

Outcome Measures

Primary Outcomes (22)

  • Postoperative myocardial infarction

    Patients experienced myocardial infarction after transurethral resection of the prostate (TURP)

    within 6 months after the first admission for TURP

  • Postoperative myocardial infarction

    Patients experienced myocardial infarction after transurethral resection of the prostate (TURP)

    within 12 months after the first admission for TURP

  • Patient's age (year-old) that developed post-TURP myocardial infarction

    We analyze age distribution of patients with post-TURP myocardial infarction

    within 6 months after the first admission for TURP

  • Patient's age (year-old) that developed post-TURP myocardial infarction

    We analyze age distribution of patients with post-TURP myocardial infarction

    within 12 months after the first admission for TURP

  • Number of patients with pre-operative diagnosed Diabetes Mellitus developing post-TURP myocardial infarction

    We analyze pre-operative diagnosed Diabetes Mellitus rate in patients who had myocardial infarction after the surgery of TURP.

    within 6 months after the first admission for TURP

  • Number of patients with pre-operative diagnosed Diabetes Mellitus developing post-TURP myocardial infarction

    We analyze pre-operative diagnosed Diabetes Mellitus rate in patients who had myocardial infarction after the surgery of TURP.

    within 12 months after the first admission for TURP

  • Number of patients with pre-operative diagnosed disorders of lipoid metabolism developing post-TURP myocardial infarction

    We analyze pre-operative diagnosed disorders of lipoid metabolism rate in patients who had myocardial infarction after the surgery of TURP.

    within 6 months after the first admission for TURP

  • Number of patients with pre-operative diagnosed disorders of lipoid metabolism developing post-TURP myocardial infarction

    We analyze pre-operative diagnosed disorders of lipoid metabolism rate in patients who had myocardial infarction after the surgery of TURP.

    within 12 months after the first admission for TURP

  • Number of patients with pre-operative diagnosed gout developing post-TURP myocardial infarction

    We analyze pre-operative diagnosed gout rate in patients who had myocardial infarction after the surgery of TURP.

    within 6 months after the first admission for TURP

  • Number of patients with pre-operative diagnosed gout developing post-TURP myocardial infarction

    We analyze pre-operative diagnosed gout rate in patients who had myocardial infarction after the surgery of TURP.

    within 12 months after the first admission for TURP

  • Number of patients with pre-operative diagnosed hypertension developing post-TURP myocardial infarction

    We analyze pre-operative diagnosed hypertension rate in patients who had myocardial infarction after the surgery of TURP.

    within 6 months after the first admission for TURP

  • Number of patients with pre-operative diagnosed hypertension developing post-TURP myocardial infarction

    We analyze pre-operative diagnosed hypertension rate in patients who had myocardial infarction after the surgery of TURP.

    within 12 months after the first admission for TURP

  • Number of patients with pre-operative diagnosed heart disease history developing post-TURP myocardial infarction

    We analyze pre-operative diagnosed heart disease rate in patients who had myocardial infarction after the surgery of TURP.

    within 6 months after the first admission for TURP

  • Number of patients with pre-operative diagnosed heart disease history developing post-TURP myocardial infarction

    We analyze pre-operative diagnosed heart disease rate in patients who had myocardial infarction after the surgery of TURP.

    within 12 months after the first admission for TURP

  • Number of patients with pre-operative diagnosed stroke history developing post-TURP myocardial infarction

    We analyze pre-operative diagnosed stroke rate in patients who had myocardial infarction after the surgery of TURP.

    within 6 months after the first admission for TURP

  • Number of patients with pre-operative diagnosed stroke history developing post-TURP myocardial infarction

    We analyze pre-operative diagnosed stroke rate in patients who had myocardial infarction after the surgery of TURP.

    within 12 months after the first admission for TURP

  • Number of patients with pre-operative diagnosed liver cirrhosis history developing post-TURP myocardial infarction

    We analyze pre-operative diagnosed liver cirrhosis rate in patients who had myocardial infarction after the surgery of TURP.

    within 6 months after the first admission for TURP

  • Number of patients with pre-operative diagnosed liver cirrhosis history developing post-TURP myocardial infarction

    We analyze pre-operative diagnosed liver cirrhosis rate in patients who had myocardial infarction after the surgery of TURP.

    within 12 months after the first admission for TURP

  • Number of patients with pre-operative diagnosed chronic obstructive pulmonary disease developing post-TURP myocardial infarction

    We analyze pre-operative diagnosed chronic obstructive pulmonary disease rate in patients who had myocardial infarction after the surgery of TURP.

    within 6 months after the first admission for TURP

  • Number of patients with pre-operative diagnosed chronic obstructive pulmonary disease developing post-TURP myocardial infarction

    We analyze pre-operative diagnosed chronic obstructive pulmonary disease rate in patients who had myocardial infarction after the surgery of TURP.

    within 12 months after the first admission for TURP

  • Number of patients with pre-operative diagnosed asthma developing post-TURP myocardial infarction

    We analyze pre-operative diagnosed asthma rate in patients who had myocardial infarction after the surgery of TURP.

    within 6 months after the first admission for TURP

  • Number of patients with pre-operative diagnosed asthma developing post-TURP myocardial infarction

    We analyze pre-operative diagnosed asthma rate in patients who had myocardial infarction after the surgery of TURP.

    within 12 months after the first admission for TURP

Secondary Outcomes (4)

  • Number of patients who had post-operative myocardial infarction after receiving general anesthesia for TURP

    within 6 months after the first admission for TURP

  • Number of patients who had post-operative myocardial infarction after receiving neuraxial anesthesia for TURP

    within 6 months after the first admission for TURP

  • Number of patients who did not have post-operative myocardial infarction after receiving general anesthesia for TURP

    within 12 months after the first admission for TURP

  • Number of patients who did not have post-operative myocardial infarction after receiving neuraxial anesthesia for TURP

    within 12 months after the first admission for TURP

Study Arms (2)

Without post-operative myocardial infarction

Patients without post-operative myocardial infarction after first admission for transurethral resection of the prostate

Other: general anesthesia or neuraxial anesthesia

With post-operative myocardial infarction

Patients with post-operative myocardial infarction after first admission for transurethral resection of the prostate

Other: general anesthesia or neuraxial anesthesia

Interventions

general anesthesia or neuraxial anesthesiaOTHER
With post-operative myocardial infarctionWithout post-operative myocardial infarction

Eligibility Criteria

Sexall
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients receiving TURP

You may qualify if:

  • Patients receiving TURP surgery (1998-2012)

You may not qualify if:

  • Patients without anesthesia records
  • Patients receiving both general and neuraxial anesthesia
  • Mortality within 12 months of TURP

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Myocardial Infarction

Interventions

Anesthesia, General

Condition Hierarchy (Ancestors)

Myocardial IschemiaHeart DiseasesCardiovascular DiseasesVascular DiseasesInfarctionIschemiaPathologic ProcessesPathological Conditions, Signs and SymptomsNecrosis

Intervention Hierarchy (Ancestors)

AnesthesiaAnesthesia and Analgesia

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 23, 2019

First Posted

August 6, 2019

Study Start

January 1, 1998

Primary Completion

December 31, 2012

Study Completion

March 22, 2016

Last Updated

August 7, 2019

Record last verified: 2015-09