NCT04046367

Brief Summary

Obesity is a major public health problem in our region and constitutes a priority of the Canary Islands Health Plan. Bariatric surgery is the most effective intervention in the treatment of obesity and its complications. However, people with obesity have high surgical risk and long-term outcomes are related to pre-surgical weight loss. In patients currently on the bariatric surgery waiting list, a randomized controlled trial will be performed in which two group interventions will be compared. One of the interventions (standard), will consist of educational modules in food and exercise, combined with cognitive-behavioral therapy. In the other, a specific training (prehabilitation) will be added to encourage physical activity and the conditioning of inspiratory muscles. The pre-surgical weight loss (principal outcome) will be compared between groups, as well as the evolution of the complications of obesity, the functional status of the patients, their physical activity, quality of life, immediate complications of surgery and days of admission.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
80

participants targeted

Target at P50-P75 for not_applicable obesity

Timeline
Completed

Started Aug 2019

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 14, 2019

Completed
2 months until next milestone

First Posted

Study publicly available on registry

August 6, 2019

Completed
16 days until next milestone

Study Start

First participant enrolled

August 22, 2019

Completed
1.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2020

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 31, 2021

Completed
Last Updated

August 6, 2019

Status Verified

August 1, 2019

Enrollment Period

1.4 years

First QC Date

June 14, 2019

Last Update Submit

August 2, 2019

Conditions

Keywords

nutritionphysical activityprehabilitation

Outcome Measures

Primary Outcomes (1)

  • Weight change

    Increase (or decrease) in weight between the start of the program and the time of surgery (measured on a calibrated scale, with Maximum increments of 0.1Kg, under the same conditions, without footwear and with light clothing)

    4-6 months

Secondary Outcomes (24)

  • Body mass index

    4-6 months

  • Body composition

    4-6 months

  • Associated complications-Blood pressure

    4-6 months

  • Associated complications-lipids

    4-6 months

  • Associated complications-glucose metabolism

    4-6 months

  • +19 more secondary outcomes

Study Arms (2)

Intervention

EXPERIMENTAL

Educational program and cognitive-behavioral intervention. The patient receives training in nutrition and cognitive-behavioral therapy, with specific training aimed at increasing physical activity, functional capacity and conditioning of the respiratory musculature (prehabilitation by a physiotherapist)

Behavioral: Prehabilitation

Control

ACTIVE COMPARATOR

Educational program and cognitive-behavioral intervention. The patient receives training in nutrition and cognitive-behavioral therapy, as well as standard instructions to increase physical activity.

Behavioral: Control

Interventions

PrehabilitationBEHAVIORAL

Prehabilitation: The intervention of a physiotherapist will be added to the components of the control group. Patients will receive practical instructions on aerobic and resistance physical activity, as well as training of their inspiratory muscles.

Also known as: Inspiratory muscle training, physical activity.
Intervention
ControlBEHAVIORAL

Standard group intervention. Educational program and cognitive-behavioral intervention. The patient receives training in nutrition and cognitive-behavioral therapy, as well as standard instructions to increase physical activity.

Control

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • People with obesity (type II-IV), on the waiting list for bariatric surgery in the Complejo Hospitalario Universitario Materno-infantil de Las Palmas

You may not qualify if:

  • any factor that, in the opinion of the researchers, limits the ability to monitor the intervention (language barrier, ...).

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Complejo Hospitalario Universitario Materno-infantil de Las Palmas

Las Palmas de Gran Canaria, Las Palmas, 35016, Spain

Location

MeSH Terms

Conditions

ObesityMotor Activity

Interventions

Preoperative ExerciseExercise

Condition Hierarchy (Ancestors)

OverweightOvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and SymptomsBehavior

Intervention Hierarchy (Ancestors)

Perioperative CarePatient CareTherapeuticsSurgical Procedures, OperativeMotor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological PhenomenaHealth ServicesHealth Care Facilities Workforce and Services

Study Officials

  • Ana M Wägner, MD, PhD

    Complejo Hospitalario Universitario Insular Materno-Infantil de Gran Canaria

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Yaiza García-Delgado, MD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Masking Details
A person external to the monitoring and evaluation of the patients will generate a random sequence (by computer), to assign the participants to their corresponding treatment group. The intervention sequence will be transcribed to cards that will be introduced in an envelope each. The envelopes will be opaque, sealed and numbered consecutively. Each time a patient agrees to participate in the trial, he/she signs the informed consent and we verify that he/she meets the inclusion criteria, but not the exclusion criteria, the corresponding envelope will be opened in correlative order. Patients will be assigned to one of two group interventions, unaware of the components in each group. The assessment of most of the outcomes will be blinded, too.
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: Randomized, controlled clinical trial, which will compare two group interventions in patients on the waiting list for bariatric surgery. Duration: 4-month intervention, with biweekly 2-hour group sessions c / un, followed by a monthly reinforcement session of 1h until surgical intervention. Intervention A: Educational program and cognitive-behavioral intervention (group control) Intervention B: Educational program and cognitive-behavioral intervention, with specific training aimed at increasing physical activity, capacity functional and conditioning of the respiratory musculature (group of intervention).
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Attending Physician

Study Record Dates

First Submitted

June 14, 2019

First Posted

August 6, 2019

Study Start

August 22, 2019

Primary Completion

December 31, 2020

Study Completion

March 31, 2021

Last Updated

August 6, 2019

Record last verified: 2019-08

Data Sharing

IPD Sharing
Will share

Anonymized data will be shared upon request

Shared Documents
STUDY PROTOCOL, SAP, ICF, CSR
Time Frame
After publication of the results
Access Criteria
Reasonable plan, acknowledgement of original investigators

Locations