Relationship of Oral Status to Coronary Artery Disease

NCT04045808 | Completed

• 1 other identifier: Cetin
• Study Type: observational
• Target: 309
• Locations: 0 countries
• Sites: N/A

Brief Summary

We hypothesized that periodontal disease and edentulism could be a risk for CAD and there might be a relationship between the oral status and the number of main coronary vessels with ≥ 50% stenosis. Therefore, primary goal of this study is to investigate the connection between oral status and the extent of coronary artery disease (CAD), which is diagnosed by angiography.

Conditions

Coronary Artery Disease; Periodontal Diseases

Keywords

coronary angiography; coronary artery disease; edentulism; periodontitis; periodontal disease

Outcome Measures

Primary Outcomes (1)

• Oral status of patients

  Oral status was categorized in three groups: Group 1 consisted of periodontally healthy subjects and patients with gingivitis. Patients having periodontitis were involved in group 2 and group 3 included edentulous subjects. Periodontal health was defined as the absence of gingivitis or periodontitis. Gingivitis was defined as BOP score of ≥ 10% and probing depth of ≤ 3mm. Diagnosis of periodontitis is based on multiple clinical and radiographic parameters. If a patient has one or more sites of inflammation (BOP), ≥ 2mm radiographic bone loss and ≥ 4mm probing depth; he/she will be diagnosed for periodontitis

  Oral status of a patient was defined in 20 minutes.

Secondary Outcomes (1)

• medical histories of participants

  Medical data was recorded in 20 minutes

Study Arms (2)

CAD(+) group

Participants were included in CAD (+) if they had more than 50% reduction in diameter in one or more major epicardial arteries,

Other: radiographic evaluations were done

CAD(-) group

patients with less than 50% reduction in epicardial artery diameter were enrolled to CAD (-) group

Other: radiographic evaluations were done

Interventions

radiographic evaluations were done OTHER

For radiographic analysis, periapical radiographs were taken from teeth with ≥ 4mm PPD using a hand held intra-oral x-ray system operating at 60kVp, 1.5 mA . The alveolar bone loss was measured by a personal computer with the Microsoft Windows XP operating system with original software.

CAD(+) group; CAD(-) group

Eligibility Criteria

• Age: 30 Years - 80 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

who were admitted to Ankara University, Faculty of Medicine, Department of Cardiology and had coronary angiography

Sponsors & Collaborators

• Baskent University: lead
• Ankara University: collaborator

MeSH Terms

Conditions

Coronary Artery Disease; Periodontal Diseases; Periodontitis

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Mouth Diseases; Stomatognathic Diseases

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD,DDS

Study Record Dates

• First Submitted: August 2, 2019
• First Posted: August 6, 2019
• Study Start: April 12, 2009
• Primary Completion: January 1, 2011
• Study Completion: February 2, 2011
• Last Updated: August 6, 2019

Record last verified: 2019-08