NON-Invasive Examinations of Coronary Artery Disease
NONCAD
1 other identifier
observational
200
1 country
1
Brief Summary
The aim of the study is to evaluate and compare the value of 5 different non-invasive diagnostic methods in patients with chest pain suspected for coronary artery disease. The investigators intend to include 200 patients over a 3 year period in the study. The participants will be recruited from patients referred to coronary angiography at the institution. Before the angiography the participants will (1) test the effect of sublingual Nitroglycerin, (2) give their medical history so mathematical models can estimate the probability of the presence of coronary artery disease, (3) take part in a contrast stress echocardiography and (4) a 2D-strain stress echocardiography and a myocardial scintigraphy. Stenosis found at the angiography will be the gold standard.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2009
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2009
CompletedFirst Submitted
Initial submission to the registry
June 22, 2009
CompletedFirst Posted
Study publicly available on registry
June 23, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2012
CompletedJune 23, 2009
June 1, 2009
3 years
June 22, 2009
June 22, 2009
Conditions
Keywords
Eligibility Criteria
All patients referred for coronary angiography at Region Hospital Herning are screened for the study and all patients complying with the in-/exclusion criteria are invited to participate in the study.
You may qualify if:
- Intermittent episodes of chest pain (more than two attacks, minimum one attack/week)
- Signed written informed consent
- Sinus rhythm (ECG)
- Age above 18 years
You may not qualify if:
- Previously (known) myocardial infarction or unstable angina with dynamic changes in the ECG or biomarkers (serology)
- CA performed earlier in life
- Known significant cardiac valve disease
- Asthma (not COPD)
- Incapable of performing an exercise test
- Malignant Disease
- Senile dementia or other conditions causing impaired cooperation
- Previous participation in the project
- NTG intolerance
- Pregnancy
- Bundle branch block (QRS \> 120 ms)
- ECG changes:
- Pathologic Q-wave in at least two leads:
- QS-complex or Q-wave \> 0.02 sec. in V2-V3
- QS-complex or Q-wave \> 0.03 sec. and \> 0.1 mV in I, II, aVL, aVF or V4-V6
- +2 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Herning Hospitallead
Study Sites (1)
Cardiovascular Research Unit, Regionhospital Herning
Herning, 7400, Denmark
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Ole May, MD, Ph.D.
Cardiovascular Research Unit
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
June 22, 2009
First Posted
June 23, 2009
Study Start
January 1, 2009
Primary Completion
January 1, 2012
Study Completion
January 1, 2012
Last Updated
June 23, 2009
Record last verified: 2009-06