Effect of the Quality of Dietary Proteins on the Sleep Young Elite Athletes and the Obese Adolescent

NCT04041934 | Unknown

• 2 other identifiers: RBHP 2018 FANTINI2018-A02680-55
• Study Type: interventional
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

Adolescence is characterized by major transitions in sleep and circadian rhythm. This rapid pivotal period increases the risks of sleep debt and poor sleep quality, leading to pronounced diurnal fatigue and drowsiness . Some adolescent's populations are more vulnerable than others to poor sleep. Obesity and elite sports involvement are two factors that have been distinctly associated with disturbed sleep. Several studies show that obesity was associated with a decrease in sleep efficiency and increased arousals . On the other hand, recent studies point out that sleep problem is widespread in young athletes which substantially increase the risks of injury, burnout and concussions . Despite the importance of sleep in holistic development, physical (i.e. recovery, metabolism, muscle growth, weight control), cognitive (i.e. learning, memory, decision-making, Vigilance) and athletic performances (Fullagar et al., 2015). A wide range of recent papers emphasize that some nutrients take part in the regulation of internal clock and sleep quality. The effect of tryptophan (Trp) on sleep was lifted on the basis of the serotonergic hypothesis. Serotonin (5-HT) is synthesized from Trp circulating in the brain following two-step procedure in raphe neurons. Serotonin, in turn, is a precursor of melatonin and both molecules contribute to the regulation of sleep-wake behaviors. However, Trp is an essential amino acid, which means that it cannot be synthesized by the organism, and must exclusively be provided via degradation of proteins from the diet. The passage of tryptophan to the brain is assured through carrier disposed at the blood-brain barrier level. However, carrier transport depends on other competitive amino acids (LNAAs: leucine, isoleucine, valine, phenylalanine, and tyrosine). Therefore, increased brain uptake of tryptophan does not depend only on Trp concentrations but rather on the blood Trp / LNAA ratio. PROTMORPHEUS trial, was designed to examine how supplementation with proteins of different Trp/LNAA ratio affect sleep on adolescents (obese, athletes) with mild sleep disturbances.

Conditions

Obese Adolescent; Elite Adolescent Athletes

Keywords

sleep; adolescent; tryptophan; athletes; obeses

Outcome Measures

Primary Outcomes (1)

• Change effect of a supplementation with proteins of different Trp/Lnaa ratio on sleep of elite adolescent athletes with mild sleep disturbances

  Efficiency of sleep (ratio of time spent in bed / sleep time)

  Change from pre-intervention

Secondary Outcomes (11)

• change in biochemical marker related to sleep

  day4 day7

• Change in biochemical markers related food intake

  day4 day7

• change in biochemical markers related to inflammation

  day4 day7

• Resting metabolic rate kcal per day

  day 7

• muscular fatigue

  day 7

Study Arms (3)

cohorte 1

EXPERIMENTAL

Tryptophan (Trp) / Large neutral amino acids (Lnaa) ratio = 0.11

Dietary Supplement: tryptophan

cohorte 2

EXPERIMENTAL

Tryptophan (Trp) / Large neutral amino acids (Lnaa) ratio = 0.07

Dietary Supplement: tryptophan

cohort 3

EXPERIMENTAL

Tryptophan (Trp) / Large neutral amino acids (Lnaa) ratio = 0.04

Dietary Supplement: tryptophan

Interventions

tryptophan DIETARY_SUPPLEMENT

Each experimental session will be carried out over a week. Adolescents will take part randomly in three sessions. In order to limit inter-individual differences, the diet of the first 3 days will be fixed to the RDA followed by 3 days where dietary intake will be supplemented with different protein (PROT REF : ratio = 0,04 PROT1 : ratio = 0,07, session PROT2 : ratio = 0,11). Tryptophan (Trp) / Large neutral amino acids (Lnaa) ratio of proteins taken varies-double-blind between sessions. All proteins had the same dose and packages. Neither the researcher nor the participants were aware of the quality of the protein.

cohort 3; cohorte 1; cohorte 2

Eligibility Criteria

• Age: 14 Years - 18 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• young athletes OR adolescent with BMI \> 90 percentiles

You may not qualify if:

• Disorders and / or pathology of sleep and chronic diseases of the digestive tract
• Medical or surgical history not compatible with the study, any other chronic illness or injury that may interfere with the subject's abilities
• Take medication that may interfere with the results of the study (corticosteroids ...) or sleeping pills
• Surgical intervention in the previous 3 months
• Regular consumption of tobacco, cannabis or alcohol
• Special diet

Sponsors & Collaborators

• University Hospital, Clermont-Ferrand: lead

Study Sites (1)

CHU de Clermont-Ferrand

Clermont-Ferrand, 63000, France

RECRUITING

MeSH Terms

Interventions

Tryptophan

Intervention Hierarchy (Ancestors)

Amino Acids, Aromatic; Amino Acids, Cyclic; Amino Acids; Amino Acids, Peptides, and Proteins; Amino Acids, Essential

Study Officials

• Livia Fantini

  University Hospital, Clermont-Ferrand

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Lise Laclautre

CONTACT

334.73.754.963; promo_interne_drci@chu-clermontferrand.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: double blind
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Tryptophan (Trp) / Large neutral amino acids (Lnaa) ratio of proteins taken varies-double-blind between sessions

Study Record Dates

• First Submitted: April 5, 2019
• First Posted: August 1, 2019
• Study Start: November 4, 2019
• Primary Completion: March 1, 2021
• Study Completion: March 1, 2022
• Last Updated: November 14, 2019

Record last verified: 2019-11

Locations

FR (1)